gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::Effector View
Entry 1 of 1 :: EFF0335 ::
FAMILY Ezrin-radixin-moesin-binding phosphoproteins
SUBFAMILY Ezrin-radixin-moesin-binding phosphoproteins
TYPE EBP50/NHERF 1

Cross References:
UniProt O14745 | O43552 | Q86WQ5 EMBL AF015926 | AF036241 | BC001443 | BC003361 | BC011777 | BC049220 | BC053350
InterPro IPR015098 | IPR001478 PDB 1G9O | 1GQ4 | 1GQ5 | 1I92 | 1SGH | 2D10 | 2OZF
GENEID 9368 MIM 604990
PFAM PF09007 | PF00595

Details:
NAME EBP50/NHERF-1-Homo sapiens
DESCRIPTION Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+)exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor ofNa(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1)(Solute carrier family 9 isoform A3 regulatory fac
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
GENE SLC9A3R1 | NHERF
SEQUENCE
MSADAAAGAPLPRLCCLEKGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLV
EVNGENVEKETHQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQA
EPPAAAEVQGAGNENEPREADKSHPEQRELRPRLCTMKKGPSGYGFNLHSDKSKPGQFIR
SVDPDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFK
KCRVIPSQEHLNGPL
FRAGMENT NO
FUNCTION Scaffold protein that connects plasma membrane proteinss with members of the ezrin/moesin/radixin family and thereby helpss to link them to the actin cytoskeleton and to regulate theirs surface expression
Interacting with G-proteins:
Family:Gq/11 REFERENCES:16182515
1GPR0002Galpha-q-Homo sapiens-2
2GPR0237Galpha-q-Homo sapiens-1


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