gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::Effector View
Entry 1 of 1 :: EFF0347 ::
FAMILY Ser Thr protein kinases
SUBFAMILY G protein coupled receptor kinases
TYPE GRK2

Cross References:
UniProt P21146 EMBL M34019
InterPro IPR015743 | IPR000239 | IPR001849 | IPR011993 | IPR000961 | IPR000719 | IPR000342 | IPR008271 | IPR002290 PDB 1OMW | 1YM7 | 2BCJ
PRODOM PD000001 GENEID 282682
PRINTS PR00717 PFAM PF00169 | PF00069 | PF00615

Details:
NAME GRK2-Bos taurus
DESCRIPTION Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G-protein-coupled receptor kinase 2).
SPECIES Bos taurus COMMON NAME Bovine NCBI Taxonomy 9913
GENE ADRBK1 | GRK2
SEQUENCE
MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFS
QKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLAC
SHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNV
ELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER
IMLSLVSTGDCPFIV
FRAGMENT NO
FUNCTION Specifically phosphorylates the agonist-occupied form ofs the beta-adrenergic and closely related receptors, probablys inducing a desensitization of them
Interacting with G-proteins:
Family:Gq/11 REFERENCES:15251227 | 14654303 | 16182515
1GPR0027Galpha-11-Bos taurus
2GPR0039Galpha-14-Bos taurus
Family:Gbeta REFERENCES:15251227 | 14654303
3GPR0145Gbeta-1-Bos taurus
4GPR0152Gbeta-2-Bos taurus
Family:Ggamma REFERENCES:15251227 | 14654303
5GPR0174Ggamma-t1-Bos taurus
6GPR0180Ggamma-2-Bos taurus
7GPR0182Ggamma-3-Bos taurus
8GPR0187Ggamma-5-Bos taurus
9GPR0191Ggamma-7-Bos taurus
10GPR0202Ggamma-12-Bos taurus
11GPR0209Ggamma-8-Bos taurus


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athina University of Athens
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Biophysics
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