gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::Effector View
Entry 1 of 1 :: EFF0351 ::
FAMILY Ser Thr protein kinases
SUBFAMILY G protein coupled receptor kinases
TYPE GRK2

Cross References:
UniProt Q64682 EMBL S81843
InterPro IPR015743 | IPR000239 | IPR001849 | IPR011993 | IPR000961 | IPR000719 | IPR000342 | IPR008271 | IPR002290
PRODOM PD000001
PRINTS PR00717 PFAM PF00169 | PF00069 | PF00615

Details:
NAME GRK2-Mesocricetus auratus
DESCRIPTION Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G-protein-coupled receptor kinase 2).
SPECIES Mesocricetus auratus COMMON NAME Golden hamster NCBI Taxonomy 10036
GENE ADRBK1 | GRK2
SEQUENCE 
MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFS
QKLGYLLFRDFCLNYLEEAKPLVEFYEEIKKYEKLETEEERVVRSREIFDSYIMKELLAC
SHPFSKNATEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNV
ELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER
IMLSLVSTGDCPFIV
 FRAGMENT NO
FUNCTION Specifically phosphorylates the agonist-occupied form ofs the beta-adrenergic and closely related receptors, probablys inducing a desensitization of them
Interacting with G-proteins:
Family:Gbeta REFERENCES:15251227 | 14654303
1GPR0288Gbeta-5-Mesocricetus auratus

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