gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::Effector View
Entry 1 of 1 :: EFF0360 ::
FAMILY Ser Thr protein kinases
SUBFAMILY G protein coupled receptor kinases
TYPE GRK3

Cross References:
UniProt P35626 | Q9UGW9 EMBL X69117 | AL022329
InterPro IPR015743 | IPR000239 | IPR001849 | IPR011993 | IPR000961 | IPR000719 | IPR000342 | IPR008271 | IPR002290
PRODOM PD000001 GENEID 157 MIM 109636
PRINTS PR00717 PFAM PF00169 | PF00069 | PF00615

Details:
NAME GRK3-Homo sapiens-2
DESCRIPTION Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G-protein-coupled receptor kinase 3).
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
GENE ADRBK2 | BARK2 | GRK3
SEQUENCE 
MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFN
QKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLSC
SHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNV
ELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER
IMLSLVSTGDCPFIV
 FRAGMENT NO
FUNCTION Specifically phosphorylates the agonist-occupied form ofs the beta-adrenergic and closely related receptors
Interacting with G-proteins:
Family:Gq/11 REFERENCES:15251227 | 14654303 | 16182515
1GPR0029Galpha-11-Homo sapiens
2GPR0002Galpha-q-Homo sapiens-2
3GPR0237Galpha-q-Homo sapiens-1
Family:Gbeta REFERENCES:15251227 | 14654303
4GPR0147Gbeta-1-Homo sapiens
5GPR0155Gbeta-2-Homo sapiens
6GPR0160Gbeta-3-Homo sapiens-1
7GPR0164Gbeta-4-Homo sapiens
8GPR0167Gbeta-5-Homo sapiens-2
9GPR0363Gbeta-3-Homo sapiens-2
10GPR0366Gbeta-5-Homo sapiens-1
11GPR0402unclassified_Gbeta-Homo sapiens
Family:Ggamma REFERENCES:15251227 | 14654303
12GPR0176Ggamma-t1-Homo sapiens
13GPR0179Ggamma-2-Homo sapiens
14GPR0183Ggamma-3-Homo sapiens
15GPR0185Ggamma-4-Homo sapiens
16GPR0188Ggamma-5-Homo sapiens-2
17GPR0192Ggamma-7-Homo sapiens
18GPR0195Ggamma-8-Homo sapiens-2
19GPR0198Ggamma-10-Homo sapiens-2
20GPR0199Ggamma-11-Homo sapiens
21GPR0203Ggamma-12-Homo sapiens
22GPR0205Ggamma-13-Homo sapiens
23GPR0210Ggamma-8-Homo sapiens-1
24GPR0253Ggamma-5-Homo sapiens-1
25GPR0364Ggamma-10-Homo sapiens-1

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athina University of Athens
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