gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::Effector View
Entry 1 of 1 :: EFF0570 ::
FAMILY PI3/PI4 kinases
SUBFAMILY Class Ia PI3Ks
TYPE PI3K alpha

Cross References:
UniProt P32871 EMBL M93252
InterPro IPR000008 | IPR000403 | IPR002420 | IPR003113 | IPR000341 | IPR001263 | IPR015433
GENEID 282306
PFAM PF00454 | PF00792 | PF02192 | PF00794 | PF00613

Details:
NAME PI3K alpha-Bos taurus
DESCRIPTION Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alphaisoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3-kinase p110) (PI3K).
SPECIES Bos taurus COMMON NAME Bovine NCBI Taxonomy 9913
GENE PIK3CA
SEQUENCE 
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVC
 FRAGMENT NO
FUNCTION Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with as preference for PtdIns(4,5)P2
Interacting with G-proteins:
Family:Gbeta REFERENCES:16182515
1GPR0145Gbeta-1-Bos taurus
2GPR0152Gbeta-2-Bos taurus
Family:Ggamma REFERENCES:16182515
3GPR0174Ggamma-t1-Bos taurus
4GPR0180Ggamma-2-Bos taurus
5GPR0182Ggamma-3-Bos taurus
6GPR0187Ggamma-5-Bos taurus
7GPR0191Ggamma-7-Bos taurus
8GPR0202Ggamma-12-Bos taurus
9GPR0209Ggamma-8-Bos taurus

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