gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::Effector View
Entry 1 of 1 :: EFF0572 ::
FAMILY PI3/PI4 kinases
SUBFAMILY Class Ia PI3Ks
TYPE PI3K alpha

Cross References:
UniProt P42336 | Q14CW1 | Q99762 EMBL Z29090 | U79143 | BC113601 | BC113603
InterPro IPR000008 | IPR000403 | IPR002420 | IPR003113 | IPR000341 | IPR001263 | IPR015433
GENEID 5290 MIM 114480 | 114500 | 171834 | 604370
PFAM PF00454 | PF00792 | PF02192 | PF00794 | PF00613

Details:
NAME PI3K alpha-Homo sapiens
DESCRIPTION Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alphaisoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3-kinase p110) (PI3K).
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
GENE PIK3CA
SEQUENCE 
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVC
 FRAGMENT NO
FUNCTION Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with as preference for PtdIns(4,5)P2
Interacting with G-proteins:
Family:Gq/11 REFERENCES:16182515
1GPR0002Galpha-q-Homo sapiens-2
2GPR0237Galpha-q-Homo sapiens-1
Family:Gbeta REFERENCES:16182515
3GPR0147Gbeta-1-Homo sapiens
4GPR0155Gbeta-2-Homo sapiens
5GPR0160Gbeta-3-Homo sapiens-1
6GPR0164Gbeta-4-Homo sapiens
7GPR0167Gbeta-5-Homo sapiens-2
8GPR0363Gbeta-3-Homo sapiens-2
9GPR0366Gbeta-5-Homo sapiens-1
10GPR0402unclassified_Gbeta-Homo sapiens
Family:Ggamma REFERENCES:16182515
11GPR0176Ggamma-t1-Homo sapiens
12GPR0179Ggamma-2-Homo sapiens
13GPR0183Ggamma-3-Homo sapiens
14GPR0185Ggamma-4-Homo sapiens
15GPR0188Ggamma-5-Homo sapiens-2
16GPR0192Ggamma-7-Homo sapiens
17GPR0195Ggamma-8-Homo sapiens-2
18GPR0198Ggamma-10-Homo sapiens-2
19GPR0199Ggamma-11-Homo sapiens
20GPR0203Ggamma-12-Homo sapiens
21GPR0205Ggamma-13-Homo sapiens
22GPR0210Ggamma-8-Homo sapiens-1
23GPR0253Ggamma-5-Homo sapiens-1
24GPR0364Ggamma-10-Homo sapiens-1

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