gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::Effector View
Entry 1 of 1 :: EFF0690 ::
FAMILY Ser Thr protein kinases
SUBFAMILY RAF protein kinases
TYPE Raf1 protein kinase

Cross References:
UniProt P11345 EMBL M15427 | BC062071
InterPro IPR002219 | IPR000719 | IPR003116 | IPR008271 PDB 1RRB
PRODOM PD000001 GENEID 24703
PRINTS PR00008 PFAM PF00130 | PF00069 | PF02196

Details:
NAME Raf1 protein kinase-Rattus norvegicus
DESCRIPTION RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf-1) (C-RAF) (cRaf).
SPECIES Rattus norvegicus COMMON NAME Rat NCBI Taxonomy 10116
GENE Raf1 | Raf
SEQUENCE
MEHIQGAWKTISNGFGLKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDSSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLQEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTASDSGVPAPPSFTMRRMRESVSRMPASSQHRYSTPHAFTF
NTSSPSSEGSLSQRQ
FRAGMENT NO
FUNCTION Involved in the transduction of mitogenic signals froms the cell membrane to the nucleus
Interacting with G-proteins:
Family:Gbeta REFERENCES:15251227
1GPR0149Gbeta-1-Rattus norvegicus-2
2GPR0157Gbeta-2-Rattus norvegicus-2
3GPR0162Gbeta-3-Rattus norvegicus
4GPR0166Gbeta-4-Rattus norvegicus
5GPR0169Gbeta-5-Rattus norvegicus
6GPR0396Gbeta-2-Rattus norvegicus-1
7GPR0397Gbeta-1-Rattus norvegicus-1
Family:Ggamma REFERENCES:15251227
8GPR0190Ggamma-5-Rattus norvegicus
9GPR0194Ggamma-7-Rattus norvegicus
10GPR0197Ggamma-8-Rattus norvegicus
11GPR0201Ggamma-11-Rattus norvegicus
12GPR0256Ggamma-2-Rattus norvegicus
13GPR0257Ggamma-3-Rattus norvegicus
14GPR0258Ggamma-4-Rattus norvegicus
15GPR0259Ggamma-10-Rattus norvegicus
16GPR0260Ggamma-12-Rattus norvegicus


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athina University of Athens
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Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory