gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR1214 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY MELATONIN RECEPTOR
SUBFAMILY MT1

Cross References:
UniProt Q61184 EMBL U52222
InterPro IPR000276 | IPR002278 | IPR000025 GPCRDB MTR1A_MOUSE
GENEID 17773
PRINTS PR00237 | PR01149 | PR00857 PFAM PF00001

Details:
NAME MELATONIN RECEPTOR_MT1_Mus musculus
DESCRIPTION Melatonin receptor type 1A (Mel-1A-R) (Mel1a melatonin receptor).
SPECIES Mus musculus COMMON NAME Mouse NCBI Taxonomy 10090
GENE Mtnr1a
SEQUENCE
MKGNVSELLNATQQAPGGGEGGRPRPSWLASTLAFILIFTIVVDILGNLLVILSVYRNKK
LRNSGNIFVVSLAVADLVVAVYPYPLVLTSILNNGWNLGYLHCQVSAFLMGLSVIGSIFN
ITGIAMNRYCYICHSLKYDKIYSNKNSLCYVFLIWMLTLIAIMPNLQTGTLQYDPRIYSC
TFTQSVSSAYTIAVVVFHFIVPMIIVIFCYLRIWVLVLQVRRRVKPDNKPKLKPQDFRNF
VTMFVVFVLFAICWAPLNLIGLIVASDPATMVPRIPEWLFVASYYLAYFNSCLNAIIYGL
LNQNFRKEYKKIIVSLCTAKMFFVESSNEEADKIKCKPSPLIPNNNLIKVDSV
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation, Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 11940583
HETERODIMER INFORMATION Forms heterodimers with Melatonin MT2 Receptors. METHOD Immunoprecipitation, Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 11940583

Coupling with G-proteins:
Family:Gi/o REFERENCES:7946354
1GPR0021Galpha-o1-Mus musculus
2GPR0227Galpha-i2-Mus musculus-2
3GPR0289Galpha-i1-Mus musculus
4GPR0331Galpha-i2-Mus musculus-1
5GPR0385Galpha-i3-Mus musculus


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