gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR1230 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY MELATONIN RECEPTOR
SUBFAMILY MT2

Cross References:
UniProt P51049 EMBL U31824
InterPro IPR000276 | IPR000025 GPCRDB MR1B1_DANRE
PRINTS PR00237 | PR00857 PFAM PF00001

Details:
NAME MELATONIN RECEPTOR_MT2_Brachydanio rerio -2
DESCRIPTION Melatonin receptor type 1B Z2.6 .
SPECIES Danio rerio COMMON NAME Zebrafish NCBI Taxonomy 7955
GENE mtnr1br | mel1br
SEQUENCE 
CHSFAYGRLCSFRNTLLLVALIWALTVLAILPNFFVGSLSYDPRVYSCTFTQTASSSYTV
VVVVVHFLVPIAVVTFCYLRIWVLVIQVRRKVKSEERSRVRPSDLRNFVTMFVVFVLFAI
CWAPLNLIGLVVAINPEVMAPRVPEWLFVVSYF
 FRAGMENT YES

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation, Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 11940583
HETERODIMER INFORMATION Forms heterodimers with Melatonin MT1 Receptors. METHOD Immunoprecipitation, Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 11940583

Coupling with G-proteins:
Family:Gi/o REFERENCES:12721330
1GPR0005Galpha-i2-Danio rerio-2
2GPR0298Galpha-i2-Danio rerio-1

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