gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR1265 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY NEUROPEPTIDE Y RECEPTOR
SUBFAMILY Y4

Cross References:
UniProt Q61041 EMBL U40189
InterPro IPR000276 | IPR001933 | IPR000611 GPCRDB NPY4R_MOUSE
PRINTS PR00237 | PR01015 | PR01012 PFAM PF00001

Details:
NAME NEUROPEPTIDE Y RECEPTOR_Y4_Mus musculus
DESCRIPTION Neuropeptide Y receptor type 4 (NPY4-R) (Pancreatic polypeptidereceptor 1) (PP1) (NPYR-D).
SPECIES Mus musculus COMMON NAME Mouse NCBI Taxonomy 10090
GENE Ppyr1 | Npy4r
SEQUENCE
MNTSHFLAPLFPGSLQGKNGTNPLDSPYNFSDGCQDSAELLAFIITTYSIETILGVLGNL
CLIFVTTRQKEKSNVTNLLIANLAFSDFLMCLICQPLTVTYTIMDYWIFGEVLCKMLTFI
QCMSVTVSILSLVLVALERHQLIINPTGWKPSIFQAYLGIVVIWFISCFLSLPFLANSTL
NDLFHYNHSKVVEFLEDKVVCFVSWSSDHHRLIYTTFLLLFQYCIPLAFILVCYIRIYQR
LQRQKHVFHAHACSSRAGQMKRINSMLMTMVTAFAVLWLPLHVFNTLEDWYQEAIPACHG
NLIFLMCHLLAMASTCVNPFIYGFLNINFKKDIKALVLTCHCRSPQGESEHLPLSTVHTD
LSKGSMRMGSKSNFI
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 14551289
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Fluorescence Resonance Energy Transfer (FRET) REFERENCES 12524448

Coupling with G-proteins:
Family:Gi/o REFERENCES:7592911
1GPR0021Galpha-o1-Mus musculus
2GPR0227Galpha-i2-Mus musculus-2
3GPR0289Galpha-i1-Mus musculus
4GPR0331Galpha-i2-Mus musculus-1
5GPR0385Galpha-i3-Mus musculus


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athina University of Athens
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Dept. of Cell Biology and Biophysics
Biophysics
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Laboratory