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gpDB::GPCR View
Entry 1 of 1 :: GPCR0138 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY ACETYLCHOLINE RECEPTOR (MUSCARINIC)
SUBFAMILY M3

Cross References:
UniProt P49578 EMBL L10617
InterPro IPR000276 | IPR001183 | IPR000995 GPCRDB ACM3_CHICK
GENEID 396364
PRINTS PR00237 | PR00243 | PR00540 PFAM PF00001

Details:
NAME ACETYLCHOLINE RECEPTOR (MUSCARINIC)_M3_Gallus gallus
DESCRIPTION Muscarinic acetylcholine receptor M3.
SPECIES Gallus gallus COMMON NAME Chicken NCBI Taxonomy 9031
GENE CHRM3
SEQUENCE 
MLTHYQLCFQKRSSQNYTVPDPTSCFDVPPWTILCQRATMIMHNNSSALPLFSNVSSFWK
RDSHGPGLLDEGASLIGSYDSPETTESFPFSTVETTNSSLNATIKDPLGGHAVWQVVLIA
FLTGIIALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMG
HWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLA
WIISFVLWAPAILFWQYFVGKRTVPLDECFIQFLSEPIITFGTAIAAFYLPVTIMSILYW
RIYKETEKRTKELAGLQASGSEAETARFVHQTGSSRSLSSYELQRQSTKRSSRRKYRRCH
FWLTMKSWEPNTDQGDQEHSSSDSWNNNDAAASLENSASSDEEDITAETRAIYSIVLKLP
GHSAILNSTKLPSSEDLNESADELQKSDTDSQEKKPKKLQPPKSIQDGGSFQKSFSKLPI
QPGSAETATASDGISSVTKTSAALPLSFKEATLAKKFALKTRSQITKRKRMSLIKEKKAA
QTLSAILFAFIITWTPYNIMVLVNTFCDCVPKTVWNLGYWLCYINSTVNPVCYALCNKMF
RNTFKMLLLCQCDKRKRRKQQYQQRQSVIFHKRIPREAS
 FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation REFERENCES 10383466
HETERODIMER INFORMATION Forms heterodimers with Muscarinic M2 Receptors. Heterodimerization results in altered internalization of the receptors METHOD Chimeric receptor reconstitution studies REFERENCES 10490911

Coupling with G-proteins:
Family:Gq/11 REFERENCES:11242080
1GPR0003Galpha-11-Gallus gallus

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athina University of Athens
 Faculty of Biology
 Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory