gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0173 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY ADENOSINE RECEPTOR
SUBFAMILY A1

Cross References:
UniProt P34970 EMBL L01700
InterPro IPR001068 | IPR001634 | IPR000276 GPCRDB AA1R_RABIT
PRINTS PR00552 | PR00424 | PR00237 PFAM PF00001

Details:
NAME ADENOSINE RECEPTOR_A1_Oryctolagus cuniculus
DESCRIPTION Adenosine receptor A1.
SPECIES Oryctolagus cuniculus COMMON NAME Rabbit NCBI Taxonomy 9986
GENE ADORA1
SEQUENCE
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA
LVIPLAILINIGPETYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKAVVT
PRRAAVAIAGCWILSLVVGLTPMFGWNNLREVQRAWAANGSVGEPVIKCEFEKVISMEYM
VYFNFFVWVLPPLLLMVLIYLEVFYLIRRQLSKKASASSGDPHKYYGKELKIAKSLALIL
FLFALSWLPLHILNCVTLFCPSCQKPSILVYTAIFLTHGNSAMNPIVYAFRIHKFRVTFL
KIWNDHFRCRPAPAGDGDEDLPEEKPND
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12123822
HETERODIMER INFORMATION Forms heterodimers with Dopamine D1 Receptor. Heterodimerization results in altered D1 receptor signalling METHOD Immunoprecipitation REFERENCES 10890919
HETERODIMER INFORMATION Forms heterodimers with Metabotropic Glutamate Receptor 1. Dimerization results in alteration of signalling METHOD Immunoprecipitation REFERENCES 11278325
HETERODIMER INFORMATION Forms heterodimers with P2Y1 Receptors. Heterodimerization results in altered ligand binding METHOD Immunoprecipitation, Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 11390975 | 12417330 | 12123822

Coupling with G-proteins:
No information


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