gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0176 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY ADENOSINE RECEPTOR
SUBFAMILY A1

Cross References:
UniProt P49892 | P87469 EMBL U28380 | U28381 | S78192 | S78199
InterPro IPR001068 | IPR001634 | IPR000276 GPCRDB AA1R_CHICK
GENEID 374212
PRINTS PR00552 | PR00424 | PR00237 PFAM PF00001

Details:
NAME ADENOSINE RECEPTOR_A1_Gallus gallus
DESCRIPTION Adenosine receptor A1.
SPECIES Gallus gallus COMMON NAME Chicken NCBI Taxonomy 9031
GENE ADORA1
SEQUENCE
MAQSVTAFQAAYISIEVLIALVSVPGNILVIWAVKMNQALRDATFCFIVSLAVADVAVGA
LVIPLAIIINIGPQTEFYSCLMMACPVLILTESSILALLAIAVDRYLRVKIPVRYKSVVT
PRRAAVAIACCWIVSFLVGLTPMFGWNNLNKVLGTRDLNVSHSEFVIKCQFETVISMEYM
VYFNFFVWVLPPLLLMLLIYLEVFNLIRTQLNKKVSSSSNDPQKYYGKELKIAKSLALVL
FLFALSWLPLHILNCITLFCPSCKTPHILTYIAIFLTHGNSAMNPIVYAFRIKKFRTAFL
QIWNQYFCCKTNKSSSSSTAETVN
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12123822
HETERODIMER INFORMATION Forms heterodimers with Dopamine D1 Receptor. Heterodimerization results in altered D1 receptor signalling METHOD Immunoprecipitation REFERENCES 10890919
HETERODIMER INFORMATION Forms heterodimers with Metabotropic Glutamate Receptor 1. Dimerization results in alteration of signalling METHOD Immunoprecipitation REFERENCES 11278325
HETERODIMER INFORMATION Forms heterodimers with P2Y1 Receptors. Heterodimerization results in altered ligand binding METHOD Immunoprecipitation, Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 11390975 | 12417330 | 12123822

Coupling with G-proteins:
Family:Gi/o REFERENCES:1662665
1GPR0217Galpha-i1-Gallus gallus
2GPR0225Galpha-i2-Gallus gallus


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory