gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0180 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY ADENOSINE RECEPTOR
SUBFAMILY A2A

Cross References:
UniProt P11617 EMBL X14052
InterPro IPR001513 | IPR001634 | IPR000276 GPCRDB AA2AR_CANFA
GENEID 403960
PRINTS PR00553 | PR00424 | PR00237 PFAM PF00001

Details:
NAME ADENOSINE RECEPTOR_A2A_Canis familiaris
DESCRIPTION Adenosine receptor A2a.
SPECIES Canis familiaris COMMON NAME Dog NCBI Taxonomy 9615
GENE ADORA2A | RDC8
SEQUENCE
MSTMGSWVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI
PFAITISTGFCAACHNCLFFACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTR
AKGIIAVCWVLSFAIGLTPMLGWNNCSQPKEGRNYSQGCGEGQVACLFEDVVPMNYMVYY
NFFAFVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVG
LFALCWLPLHIINCFTFFCPECSHAPLWLMYLTIVLSHTNSVVNPFIYAYRIREFRQTFR
KIIRSHVLRRREPFKAGGTSARALAAHGSDGEQISLRLNGHPPGVWANGSAPHPERRPNG
YTLGLVSGGIAPESHGDMGLPDVELLSHELKGACPESPGLEGPLAQDGAGVS
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12804599
HETERODIMER INFORMATION Forms heterodimers with Dopamine D2. Heterodimerization results in co-desensitization and co-internalization of the receptors METHOD Immunoprecipitation REFERENCES 11872740
HETERODIMER INFORMATION Forms heterodimers with Metabotropic Glutamate Receptors 5. Dimerization results in enhanced ERK activity METHOD Immunoprecipitation REFERENCES 12189203

Coupling with G-proteins:
Family:Gs REFERENCES:1662665
1GPR0120Galpha-s-Canis familiaris


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory