gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR1912 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY OPIOID AND OPIOID-LIKE RECEPTOR
SUBFAMILY MU OPIOID PEPTIDE (MOR)

Cross References:
UniProt P35372 | Q12930 | Q7Z2D8 | Q9UCZ4 | Q9UN57 EMBL L25119 | L29301 | U12569 | AY521028 | AY587764 | BC074927 | AY292290 | AY292291 | AF153500
InterPro IPR000276 | IPR000105 | IPR001418 GPCRDB OPRM_HUMAN
GENEID 4988 MIM 600018
PRINTS PR00237 | PR00537 | PR00384 PFAM PF00001

Details:
NAME OPIOID AND OPIOID-LIKE RECEPTOR_MU OPIOID PEPTIDE (MOR)_Homo sapiens-1
DESCRIPTION Mu-type opioid receptor (MOR-1).
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
GENE OPRM1 | MOR1
SEQUENCE
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCP
PTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALAT
STLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDF
RTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFI
FAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHI
YVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNI
EQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12217652
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation REFERENCES 10842167
HETERODIMER INFORMATION Forms heterodimers with delta Opioid Peptide Receptor. Dimerization results in Changing the binding properties of opiate ligands and altered G-protein coupling METHOD Immunoprecipitation REFERENCES 10842167 | 11069979
HETERODIMER INFORMATION Forms heterodimers with SST2 RECEPTORS. Dimerization results in cross-modulation of receptor phosphorylation, internalization and desensitization METHOD Immunoprecipitation REFERENCES 11896051

Coupling with G-proteins:
Family:Gi/o REFERENCES:8393525
1GPR0020Galpha-o1-Homo sapiens
2GPR0109Galpha-i3-Homo sapiens
3GPR0218Galpha-i1-Homo sapiens-1
4GPR0226Galpha-i2-Homo sapiens-2
5GPR0261Galpha-i1-Homo sapiens-2
6GPR0334Galpha-o-Homo sapiens
7GPR0365Galpha-i2-Homo sapiens-1


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory