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gpDB::GPCR View
Entry 1 of 1 :: GPCR0238 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY ADRENOCEPTOR (A2-ADRENOCEPTOR)
SUBFAMILY A2A(Adrenoceptor)

Cross References:
UniProt Q90WY4 EMBL AY048971
InterPro IPR015695 | IPR002233 | IPR000276 GPCRDB ADA2A_DANRE
PRINTS PR01103 | PR00237 PFAM PF00001

Details:
NAME ADRENOCEPTOR (A2-ADRENOCEPTOR)_A2A(Adrenoceptor)_Brachydanio rerio
DESCRIPTION Alpha-2A adrenergic receptor (Alpha-2A adrenoceptor) (Alpha-2Aadrenoreceptor) (Alpha(2A)AR).
SPECIES Danio rerio COMMON NAME Zebrafish NCBI Taxonomy 7955
GENE adra2a
SEQUENCE
MICGANATNGTNATKEYTLLVALPLSIAVGLLILLIIFGNVLVIIAVFTSRALRAPQNLF
LVSLASADILVATLVMPFSLANELMGMWTFGGVWCEIYLALDVLFCTASITHLCAISLDR
YWSITQAIEYNLKRTPQRIKRIIFIVWIIAAVISCPPLITMKKSEGDICDINKEKWYIVS
SCIGSFFLPCIIMVLVYIRIYQIAKKRTRAPPGDHRKNEVGKKENDPHEKLNGIQNAEPD
DKDEINGVDMEESSSSDHKVSNPCSLKKKSSKGKTKLSQIKPGDGDKTEACQTTKASRWK
GRQNREKRFTFVLAVVIGVFVICWFPFFFTYTFTAFCDCCVPETLFKFFFWFGYCNSSLN
PIIYTIFNNDFRRSFKKILCRRDKRRVV
FRAGMENT NO

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Dimerization:
HETERODIMER INFORMATION Forms heterodimers with B1 Adrenoceptors. Heterodimerization results in altered ligand binding and internalization of the receptor METHOD Immunoprecipitation REFERENCES 12529373

Scaffold:
TYPE 14-3-3 ksi REFERENCES 10224112
TYPE Spinophilin/neurabin II REFERENCES 11154706

Coupling with G-proteins:
Family:Gi/o REFERENCES:8662784
1GPR0005Galpha-i2-Danio rerio-2
2GPR0298Galpha-i2-Danio rerio-1


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory