gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR2478 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY SOMATOSTATIN RECEPTOR
SUBFAMILY SST2

Cross References:
UniProt Q8UWL5 EMBL AF329945
InterPro IPR000276 | IPR000586 | IPR002074 GPCRDB Q8UWL5_FUGRU
PRINTS PR00237 | PR00246 | PR00588 PFAM PF00001

Details:
NAME SOMATOSTATIN RECEPTOR_SST2_Fugu rubripes
DESCRIPTION Somatostatin receptor 2.
SPECIES Fugu rubripes COMMON NAME Japanese pufferfish NCBI Taxonomy 31033
GENE SSTR2
SEQUENCE
MDAWILPPSPLNLSDHLLYDGFEQANGSDLHANRTDHSLNKTSTVVITCMYFLVCAVGLC
GNALVIYVILRYAKMKTVTNIYILNLAVADVLFMLGLPFIAIQLALVHWPFGPVLCRVVM
TVDSLNQFTSIFCLMVMSIDRYLAVVHPIKSTKWRKPRVAKTINVAVWGASLVVNLPIVI
YSGIITKQDGCFCTIVWPEPEEAYYTAFMIYTFILGFFLPLLVISLCYVFIIVKVKSSGI
RVGSSKRKRSERKVTRMVSIVVAVFVLCWLPFYVFNVTSVTGSISATHVLRSTFAFVVVL
GYANSCANPILYAFLSENFKKSFQNVLCLQKVGGLDEAERSDSRQDKSRMINDPTETRST
LLNGDLQTSI
FRAGMENT NO

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Dimerization:
HETERODIMER INFORMATION Forms heterodimer with SST3 Receptor. Dimerization results in inactivation of SST3 Receptor function METHOD Immunoprecipitation REFERENCES 11134004
HETERODIMER INFORMATION Forms heterodimers with MU OPIOID RECEPTORS. Dimerization results in cross-modulation of receptor phosphorylation, internalization and desensitization METHOD Immunoprecipitation REFERENCES 11896051

Scaffold:
TYPE Shank1/SSTRIP( somatostatin receptor interacting protein) /synamon REFERENCES 10551867
TYPE Shank2/ProSAP1( proline-rich synapse-associated protein 1) /CortBP1 REFERENCES 10373412

Coupling with G-proteins:
No information


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athina University of Athens
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Dept. of Cell Biology and Biophysics
Biophysics
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Laboratory