gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR2479 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY SOMATOSTATIN RECEPTOR
SUBFAMILY SST2

Cross References:
UniProt Q9DGQ6 EMBL AF139597
InterPro IPR000276 | IPR000586 | IPR002074 GPCRDB Q9DGQ6_CARAU
PRINTS PR00237 | PR00246 | PR00588 PFAM PF00001

Details:
NAME SOMATOSTATIN RECEPTOR_SST2_Carassius auratus
DESCRIPTION Somatostatin receptor type two.
SPECIES Carassius auratus COMMON NAME Goldfish NCBI Taxonomy 7957
GENE sst2
SEQUENCE
MDTKWTFMPNSNMSLPDRLLNDSFFPGNESDFGLEMYPHNSTHPGFDQTSSVVITFVYFV
VCAVGLCGNALVMYVILRYAKMKTVTNIYILNLAVADVLCMLSLPFIAIQLSLLHWPFGS
AICRVVLTADSMNQFTSIFFLTVMSFDRYLAVVHPIKSTKWRKPRMAKSISLAMWVISLL
VNLPIMIYSGVNVKKNEARTCTMLWPEPQNTYYTVFIFYTFFMGFFLPLIVICMCYLLIV
IKVKSSGMRVCSSKRKRSERKVTRMVSIVVVVFVLCWLPFYVFNVTSVTGTVPTTPVLKS
TFDFVVVLGYANSCANPILYAFLSDNFKKSFQNVLCLKRVGGLDEIERSDSRQDRTRMVN
DVMSETHNAALLNGDLQTSI
FRAGMENT NO

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Dimerization:
HETERODIMER INFORMATION Forms heterodimer with SST3 Receptor. Dimerization results in inactivation of SST3 Receptor function METHOD Immunoprecipitation REFERENCES 11134004
HETERODIMER INFORMATION Forms heterodimers with MU OPIOID RECEPTORS. Dimerization results in cross-modulation of receptor phosphorylation, internalization and desensitization METHOD Immunoprecipitation REFERENCES 11896051

Scaffold:
TYPE Shank1/SSTRIP( somatostatin receptor interacting protein) /synamon REFERENCES 10551867
TYPE Shank2/ProSAP1( proline-rich synapse-associated protein 1) /CortBP1 REFERENCES 10373412

Coupling with G-proteins:
No information


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