gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR2482 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY SOMATOSTATIN RECEPTOR
SUBFAMILY SST2

Cross References:
UniProt P30874 | Q4VBP0 | Q96GE0 | Q96TF2 | Q9BWH1 EMBL M81830 | AF184174 | AF184174 | AB065911 | AY236542 | BT019926 | BC000256 | BC009522 | BC019610 | BC095495
InterPro IPR000276 | IPR000586 | IPR002074 GPCRDB SSR2_HUMAN
GENEID 6752 MIM 182452
PRINTS PR00237 | PR00246 | PR00588 PFAM PF00001

Details:
NAME SOMATOSTATIN RECEPTOR_SST2_Homo sapiens
DESCRIPTION Somatostatin receptor type 2 (SS2R) (SRIF-1).
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
GENE SSTR2
SEQUENCE
MDMADEPLNGSHTWLSIPFDLNGSVVSTNTSNQTEPYYDLTSNAVLTFIYFVVCIIGLCG
NTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMT
VDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIY
AGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGI
RVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVL
TYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDSKQDKSRLNETTETQRTL
LNGDLQTSI
FRAGMENT NO

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Dimerization:
HETERODIMER INFORMATION Forms heterodimer with SST3 Receptor. Dimerization results in inactivation of SST3 Receptor function METHOD Immunoprecipitation REFERENCES 11134004
HETERODIMER INFORMATION Forms heterodimers with MU OPIOID RECEPTORS. Dimerization results in cross-modulation of receptor phosphorylation, internalization and desensitization METHOD Immunoprecipitation REFERENCES 11896051

Scaffold:
TYPE Shank1/SSTRIP( somatostatin receptor interacting protein) /synamon REFERENCES 10551867
TYPE Shank2/ProSAP1( proline-rich synapse-associated protein 1) /CortBP1 REFERENCES 10373412

Coupling with G-proteins:
Family:Gi/o REFERENCES:7622071
1GPR0020Galpha-o1-Homo sapiens
2GPR0109Galpha-i3-Homo sapiens
3GPR0218Galpha-i1-Homo sapiens-1
4GPR0226Galpha-i2-Homo sapiens-2
5GPR0261Galpha-i1-Homo sapiens-2
6GPR0334Galpha-o-Homo sapiens
7GPR0365Galpha-i2-Homo sapiens-1


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory