gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR2486 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY SOMATOSTATIN RECEPTOR
SUBFAMILY SST3

Cross References:
UniProt P32745 | Q53ZR7 EMBL M96738 | AY277678 | AY322541 | CR456585 | Z82188 | BC096829
InterPro IPR000276 | IPR000586 | IPR001856 GPCRDB SSR3_HUMAN
GENEID 6753 MIM 182453
PRINTS PR00237 | PR00246 | PR00589 PFAM PF00001

Details:
NAME SOMATOSTATIN RECEPTOR_SST3_Homo sapiens
DESCRIPTION Somatostatin receptor type 3 (SS3R) (SSR-28).
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
GENE SSTR3
SEQUENCE
MDMLHPSSVSTTSEPENASSAWPPDATLGNVSAGPSPAGLAVSGVLIPLVYLVVCVVGLL
GNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVM
AVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVV
FSGVPRGMSTCHMQWPEPAAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRV
WAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVCPLPEEPAFFGLYFLVVA
LPYANSCANPILYGFLSYRFKQGFRRVLLRPSRRVRSQEPTVGPPEKTEEEDEEEEDGEE
SREGGKGKEMNGRVSQITQPGTSGQERPPSRVASKEQQLLPQEASTGEKSSTMRISYL
FRAGMENT NO

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Dimerization:
HETERODIMER INFORMATION Forms heterodimer with SST2 Receptor. Dimerization results in inactivation of SST3 Receptor function METHOD Immunoprecipitation REFERENCES 11134004

Coupling with G-proteins:
Family:Gi/o REFERENCES:1337145
1GPR0020Galpha-o1-Homo sapiens
2GPR0109Galpha-i3-Homo sapiens
3GPR0218Galpha-i1-Homo sapiens-1
4GPR0226Galpha-i2-Homo sapiens-2
5GPR0261Galpha-i1-Homo sapiens-2
6GPR0334Galpha-o-Homo sapiens
7GPR0365Galpha-i2-Homo sapiens-1


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory