gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR2492 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY SOMATOSTATIN RECEPTOR
SUBFAMILY SST5

Cross References:
UniProt P35346 | P34988 | Q9UJI5 EMBL L14865 | D16827 | AE006466 | AL031713
InterPro IPR000276 | IPR000586 | IPR001184 GPCRDB SSR5_HUMAN
GENEID 6755 MIM 182455
PRINTS PR00237 | PR00246 | PR00591 PFAM PF00001

Details:
NAME SOMATOSTATIN RECEPTOR_SST5_Homo sapiens
DESCRIPTION Somatostatin receptor type 5 (SS5R).
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
GENE SSTR5
SEQUENCE
MEPLFPASTPSWNASSPGAASGGGDNRTLVGPAPSAGARAVLVPVLYLLVCAAGLGGNTL
VIYVVLRFAKMKTVTNIYILNLAVADVLYMLGLPFLATQNAASFWPFGPVLCRLVMTLDG
VNQFTSVFCLTVMSVDRYLAVVHPLSSARWRRPRVAKLASAAAWVLSLCMSLPLLVFADV
QEGGTCNASWPEPVGLWGAVFIIYTAVLGFFAPLLVICLCYLLIVVKVRAAGVRVGCVRR
RSERKVTRMVLVVVLVFAGCWLPFFTVNIVNLAVALPQEPASAGLYFFVVILSYANSCAN
PVLYGFLSDNFRQSFQKVLCLRKGSGAKDADATEPRPDRIRQQQEATPPAHRAAANGLMQ
TSKL
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation, Fluorescence Resonance Energy Transfer (FRET) REFERENCES 10713101
HETERODIMER INFORMATION Forms heterodimer with SST1 Receptor. Dimerization allows internalization of SST1 Receptor METHOD Photobleaching Fluorescence Resonance Energy Transfer (FRET) REFERENCES 10713101
HETERODIMER INFORMATION Forms heterodimer with Dopamine Receptor D2. Dimerization results in increased ligand binding affnity and enhanced signalling METHOD Photobleaching Fluorescence Resonance Energy Transfer (FRET) REFERENCES 10753124

Coupling with G-proteins:
Family:Gi/o REFERENCES:8373420
1GPR0020Galpha-o1-Homo sapiens
2GPR0109Galpha-i3-Homo sapiens
3GPR0218Galpha-i1-Homo sapiens-1
4GPR0226Galpha-i2-Homo sapiens-2
5GPR0261Galpha-i1-Homo sapiens-2
6GPR0334Galpha-o-Homo sapiens
7GPR0365Galpha-i2-Homo sapiens-1


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory