gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
Introduction Navigation Text Search Blast Search Pattern Search User Manual

gpDB::GPCR View
Entry 1 of 1 :: GPCR2521 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY THYROTROPIN-RELEASING HORMONE RECEPTOR
SUBFAMILY TRH1

Cross References:
UniProt O46639 EMBL D83964
InterPro IPR000276 | IPR009144 | IPR002120 GPCRDB TRFR_BOVIN
GENEID 281549
PRINTS PR00237 | PR00751 | PR01846 PFAM PF00001

Details:
NAME THYROTROPIN-RELEASING HORMONE RECEPTOR_TRH1_Bos taurus
DESCRIPTION Thyrotropin-releasing hormone receptor (TRH-R) (Thyroliberinreceptor).
SPECIES Bos taurus COMMON NAME Bovine NCBI Taxonomy 9913
GENE TRHR
SEQUENCE
MENETGSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPT
NCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFT
IERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSIYCMLWFFLLDLNISTYKDAIVVSCG
YKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSNMWKNDSTH
QNKNLNSKTSNRYFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENW
FLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPVEKPANYSVALSYSVIKES
DRFSTELDDVTVTDTYLSATKVSFDDTCLASEITFNQS
FRAGMENT NO

Homepage

Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12393857 | 11278883
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation REFERENCES 12023974
HETERODIMER INFORMATION Forms heterodimers with TRH2 Receptors. Dimerization results in altered traffcking and beta-arrestin interactions METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12393857

Coupling with G-proteins:
Family:Gq/11 REFERENCES:2175902
1GPR0027Galpha-11-Bos taurus


Designed for viewing with Internet Explorer 4 or above, Netscape 6 or above.
contact biodbbiol.uoa.gr
for comments, corrections and
data (sequence) submission.
athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory