gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR2523 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY THYROTROPIN-RELEASING HORMONE RECEPTOR
SUBFAMILY TRH1

Cross References:
UniProt Q28596 EMBL X95285
InterPro IPR000276 | IPR009144 | IPR002120 GPCRDB TRFR_SHEEP
GENEID 443425
PRINTS PR00237 | PR00751 | PR01846 PFAM PF00001

Details:
NAME THYROTROPIN-RELEASING HORMONE RECEPTOR_TRH1_Ovis aries
DESCRIPTION Thyrotropin-releasing hormone receptor (TRH-R) (Thyroliberinreceptor).
SPECIES Ovis aries COMMON NAME Sheep NCBI Taxonomy 9940
GENE TRHR
SEQUENCE
MENETGSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPT
NCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFT
IERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSIYCMLWFFLLDLNISTYKDAIVVSCG
YKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLSPIPSDPKENSNTWKNDSTH
QNKNLNSKTSNRYFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENW
FLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPVEKPANYSVALNYSVIKES
DHFSTELDDITVTDTYLSATKVSFDDTCLASEVTFSQS
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12393857 | 11278883
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation REFERENCES 12023974
HETERODIMER INFORMATION Forms heterodimers with TRH2 Receptors. Dimerization results in altered traffcking and beta-arrestin interactions METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12393857

Coupling with G-proteins:
No information


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athina University of Athens
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Biophysics
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Laboratory