gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR2556 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY VASOPRESSIN AND OXYTOCIN RECEPTOR
SUBFAMILY OT

Cross References:
UniProt Q28756 EMBL X87986
InterPro IPR000276 | IPR002062 | IPR001817 GPCRDB OXYR_SHEEP
PRINTS PR00237 | PR00665 | PR00896 PFAM PF00001

Details:
NAME VASOPRESSIN AND OXYTOCIN RECEPTOR_OT_Ovis aries
DESCRIPTION Oxytocin receptor (OT-R).
SPECIES Ovis aries COMMON NAME Sheep NCBI Taxonomy 9940
GENE OXTR
SEQUENCE 
MEGAFAANWSAEAVNGSAAPPGTEGNRTAGPPQRNEALARVEVAVLSLILFLALSGNACV
LLALRTTRHKHSRLFFFMKHLSIADLAVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQV
VGMFASTYLLLLMSLDRCLAICQPLRSLRRRTDRLAVLATWLGCLVASAPQVHIFSLREV
ADGVFDCWAVFIQPWGPKAYITWITLAVYIVPVIVLAACYGLISFKIWQNLRLKTEAAAA
EASAGAEGAAADCAGRAALARVSNVKLISKAKIRTVKMTFIVVLAFIVCWTPFFFKQMWS
VWDADAPKEASAFIIAMLLASLNSCCNPWIYMLFTGHLFQDLVQRFLCCSFRRLKGSQLG
ETSVTKKIHSYTFVLSRHSSSQRSCSQPSTV
 FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12554793
HETERODIMER INFORMATION Forms functional heterodimers with V2 Receptors METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12554793
HETERODIMER INFORMATION Forms functional heterodimers with V1A Receptors METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12554793

Coupling with G-proteins:
No information

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athina University of Athens
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 Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory