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gpDB::GPCR View
Entry 1 of 1 :: GPCR0039 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY 5-HYDROXYTRYPTAMINE RECEPTOR
SUBFAMILY 5-HT-1D

Cross References:
UniProt Q61224 | Q61615 EMBL X94908 | L20335
InterPro IPR000505 | IPR002231 | IPR000276 GPCRDB 5HT1D_MOUSE
PRINTS PR00514 | PR01101 | PR00237 PFAM PF00001

Details:
NAME 5-HYDROXYTRYPTAMINE RECEPTOR_5-HT-1D_Mus musculus-2
DESCRIPTION 5-hydroxytryptamine receptor 1D (5-HT-1D) (Serotonin receptor 1D).
SPECIES Mus musculus COMMON NAME Mouse NCBI Taxonomy 10090
GENE Htr1d | Gpcr14
SEQUENCE
MSLPNQSLEGLPQEASNRSLNATGAWDPEVLQALRISLVVVLSVITLATVLSNAFVLTTI
LLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCT
ASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHE
EMSDCLVNTSQISYTIYSTCGAFYIPSILLIILYGRIYVAARSRILNPPSLYGKRFTTAQ
LITGSAGSSLCSLNPSLHESHTHTVGSPLFFNQVKIKLADSILERKRISAARERKATKTL
GIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPVIYTVFNEDF
RQAFQKVVHFRKAS
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation REFERENCES 10452531
HETERODIMER INFORMATION Forms functional heterodimers when co-expressed with 5-HT-1B Receptor. METHOD Immunoprecipitation REFERENCES 10452531

Coupling with G-proteins:
Family:Gi/o REFERENCES:1565658
1GPR0021Galpha-o1-Mus musculus
2GPR0227Galpha-i2-Mus musculus-2
3GPR0289Galpha-i1-Mus musculus
4GPR0331Galpha-i2-Mus musculus-1
5GPR0385Galpha-i3-Mus musculus


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athina University of Athens
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Biophysics
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Laboratory