gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0418 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY ANGIOTENSIN RECEPTOR
SUBFAMILY AT1

Cross References:
UniProt Q9TTU4 EMBL AF195509
InterPro IPR000147 | IPR000248 | IPR000276 GPCRDB Q9TTU4_9CETA
PRINTS PR00241 | PR00636 | PR00237 PFAM PF00001

Details:
NAME ANGIOTENSIN RECEPTOR_AT1_Sus sp
DESCRIPTION Angiotensin II receptor .
SPECIES Sus sp COMMON NAME - NCBI Taxonomy 9826
GENE -
SEQUENCE 
FLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFR
DVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTN
SYGKNRITRDQVLKMAAAV
 FRAGMENT YES

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD functional complementation REFERENCES 8576145
HETERODIMER INFORMATION Forms heterodimer with AT2 Receptor. After the dimerization the AT2 receptor antagonizes function of the AT1 receptor METHOD Immunoprecipitation REFERENCES 11507095
HETERODIMER INFORMATION Forms heterodimer with Bradykinin B2 Receptor. Dimerization results in increased signalling activity METHOD Immunoprecipitation REFERENCES 10993080

Scaffold:
TYPE eNOS( endothelial nitric oxide synthase) /cNOS/NOS3 REFERENCES 12842859
TYPE JAK2( Janus kinase) REFERENCES 9287353

Coupling with G-proteins:
No information

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athina University of Athens
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 Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory