gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0437 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY ANGIOTENSIN RECEPTOR
SUBFAMILY AT2

Cross References:
UniProt P50052 | Q13016 | Q6FGY7 EMBL U20860 | L34579 | U10273 | U15592 | U16957 | U27478 | AY536522 | AY322542 | AY324607 | CR541969 | AL732602 | BC095504 | X87723
InterPro IPR000147 | IPR000248 | IPR001186 | IPR000276 GPCRDB AGTR2_HUMAN
GENEID 186 MIM 300034
PRINTS PR00241 | PR00636 | PR00993 | PR00237 PFAM PF00001

Details:
NAME ANGIOTENSIN RECEPTOR_AT2_Homo sapiens
DESCRIPTION Type-2 angiotensin II receptor (AT2).
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
GENE AGTR2
SEQUENCE
MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFL
VNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVF
GSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFY
FRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLK
TNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLAL
PFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMET
FVS
FRAGMENT NO

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Dimerization:
HETERODIMER INFORMATION Forms heterodimer with AT1 Receptor. After the dimerization the AT2 receptor antagonizes function of the AT1 receptor METHOD Immunoprecipitation REFERENCES 11507095

Coupling with G-proteins:
Family:Gi/o REFERENCES:8663053
1GPR0020Galpha-o1-Homo sapiens
2GPR0109Galpha-i3-Homo sapiens
3GPR0218Galpha-i1-Homo sapiens-1
4GPR0226Galpha-i2-Homo sapiens-2
5GPR0261Galpha-i1-Homo sapiens-2
6GPR0334Galpha-o-Homo sapiens
7GPR0365Galpha-i2-Homo sapiens-1


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athina University of Athens
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Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory