gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0438 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY ANGIOTENSIN RECEPTOR
SUBFAMILY AT2

Cross References:
UniProt Q28929 EMBL S81979
InterPro IPR000147 | IPR000248 | IPR001186 | IPR000276 GPCRDB AGTR2_SHEEP
PRINTS PR00241 | PR00636 | PR00993 | PR00237 PFAM PF00001

Details:
NAME ANGIOTENSIN RECEPTOR_AT2_Ovis aries
DESCRIPTION Type-2 angiotensin II receptor .
SPECIES Ovis aries COMMON NAME Sheep NCBI Taxonomy 9940
GENE AGTR2
SEQUENCE
PVLYYIIWGVGFLVNTIVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSHR
YDWIFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLG
WCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFI
ATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVI
NSCEVIAVIDLALPFAILLG
FRAGMENT YES

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Dimerization:
HETERODIMER INFORMATION Forms heterodimer with AT1 Receptor. After the dimerization the AT2 receptor antagonizes function of the AT1 receptor METHOD Immunoprecipitation REFERENCES 11507095

Coupling with G-proteins:
No information


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athina University of Athens
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Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory