gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0470 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY BRADYKININ RECEPTOR
SUBFAMILY B2

Cross References:
UniProt Q9GLX8 EMBL AB051422
InterPro IPR001504 | IPR000496 | IPR000276 GPCRDB BKRB2_PIG
GENEID 397277
PRINTS PR00425 | PR00994 | PR00237 PFAM PF00001

Details:
NAME BRADYKININ RECEPTOR_B2_Sus scrofa
DESCRIPTION B2 bradykinin receptor (BK-2 receptor) (B2R).
SPECIES Sus scrofa COMMON NAME Pig NCBI Taxonomy 9823
GENE BDKRB2
SEQUENCE
MLNLTSQVPEPALNGTLPQSSSCFHSDWWNWLNTIQAPFLWVLFLLAALENIFVLSVFCL
HKNSCTVAEIYLGNLAMADLILALGLPFWAITIANHFDWLFGEVLCRVVNTMIYMNLYSS
ICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWGCTLLLSSPMLAFRTMHEYAAE
GHNVTACIIKYPSRSWMVFTNILLNSVGFLLPLSIITYCTVQILQVLRNNEMQKFKEIQT
ERKATVLVLAVLLLFVVCWLPFQISTFLDTLLRLGVLSGCWDEHAVDVITQISSYVAYSN
SGLNPLVYVIVGKRFRKKSREVYRVLCQKGGCMGEPVQMENSMGTLRTSISVERQIHKLQ
DWAGKKQ
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Cross-linking in the presence of agonist REFERENCES 10473556
HETERODIMER INFORMATION Forms heterodimer with Angiotensin AT1 Receptor. Dimerization results in increased signalling activity METHOD Immunoprecipitation REFERENCES 10993080

Scaffold:
TYPE eNOS( endothelial nitric oxide synthase) /cNOS/NOS3 REFERENCES 10681501
TYPE nNOS( neuronal nitric oxide synthase) NOS1 REFERENCES 10681501

Coupling with G-proteins:
No information


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory