gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0592 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY CHEMOKINE RECEPTOR (CC)
SUBFAMILY CCR5

Cross References:
UniProt O62743 | O62744 | O62745 | O62746 EMBL AF051902 | AF051903 | AF051904 | AF051905
InterPro IPR002240 | IPR000355 | IPR000276 GPCRDB CCR5_CERTO
PRINTS PR00657 | PR01110 | PR00237 PFAM PF00001

Details:
NAME CHEMOKINE RECEPTOR (CC)_CCR5_Cercocebus torquatus atys
DESCRIPTION C-C chemokine receptor type 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5)(CD195 antigen).
SPECIES Cercocebus torquatus atys COMMON NAME Red-crowned mangabey NCBI Taxonomy 9531
GENE CCR5 | CMKBR5
SEQUENCE
MDYQVSSPTYDIDYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNILVVLILINCKR
LKSMTDIYLLNLAISDLLFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFII
LLTIDRYLAIVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQREGLHYTCSP
HFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTI
MIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFV
GEKFRNYLLVFFQKHIAKRFCKCCSIFQQEASERASSVYTRSTGEQEISVGL
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12089144
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation REFERENCES 10725362
HETERODIMER INFORMATION Forms heterodimers with Chemokine CCR2 Receptor. Dimerization increases the sensitivity and range of signalling pathways activated METHOD Immunoprecipitation, Fluorescence Resonance Energy Transfer (FRET) REFERENCES 11350939

Coupling with G-proteins:
No information


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athina University of Athens
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Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory