gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0649 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY CHEMOKINE RECEPTOR (CX3C)
SUBFAMILY CXCR4

Cross References:
UniProt P61073 | O60835 | P30991 | P56438 | Q9UKN2 EMBL L01639 | M99293 | X71635 | L06797 | D10924 | AF005058 | AF052572 | AF025375 | Y14739 | AJ224869 | AF147204 | AY242129 | AY728138 | BT006660 | BC020968
InterPro IPR000355 | IPR001277 | IPR000276 GPCRDB CXCR4_HUMAN
GENEID 7852 MIM 162643 | 193670
PRINTS PR00657 | PR00645 | PR00237 PFAM PF00001

Details:
NAME CHEMOKINE RECEPTOR (CX3C)_CXCR4_Homo sapiens-1
DESCRIPTION C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (Stromal cell-derived factor 1 receptor) (SDF-1 receptor) (Fusin) (Leukocyte-derivedseven transmembrane domain receptor) (LESTR) (LCR1) (FB22) (NPYRL)(HM89) (CD184 antigen).
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
GENE CXCR4
SEQUENCE
MEGISIYTSDNYTEEMGSGDYDSMKEPCFREENANFNKIFLPTIYSIIFLTGIVGNGLVI
LVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNL
YSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEA
DDRYICDRFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKT
TVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPI
LYAFLGAKFKTSAQHALTSVSRGSSLKILSKGKRGGHSSVSTESESSSFHSS
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12433920 | 12089144

Coupling with G-proteins:
Family:Gi/o REFERENCES:8629022
1GPR0020Galpha-o1-Homo sapiens
2GPR0109Galpha-i3-Homo sapiens
3GPR0218Galpha-i1-Homo sapiens-1
4GPR0226Galpha-i2-Homo sapiens-2
5GPR0261Galpha-i1-Homo sapiens-2
6GPR0334Galpha-o-Homo sapiens
7GPR0365Galpha-i2-Homo sapiens-1


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory