gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0680 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY CHEMOKINE RECEPTOR (CX3C)
SUBFAMILY CXCR4

Cross References:
UniProt Q9DGI1 EMBL AF294794
InterPro IPR000355 | IPR001277 | IPR000276 GPCRDB Q9DGI1_CHICK
GENEID 395324
PRINTS PR00657 | PR00645 | PR00237 PFAM PF00001

Details:
NAME CHEMOKINE RECEPTOR (CX3C)_CXCR4_Gallus gallus
DESCRIPTION Chemokine receptor CXCR4.
SPECIES Gallus gallus COMMON NAME Chicken NCBI Taxonomy 9031
GENE CXCR4
SEQUENCE
MDGLDLSSGILIEFADNGSEEIGSADYGDYGEPCFQHENADFNRIFLPTIYSIIFLTGII
GNGLVIIVMGYQKKQRSMTDKYRLHLSVADLLFVITLPFWSVDAAISWYFGNVLCKAVHV
IYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKIVYVGVWLPAVLLTVPDIIF
ASTSEVEGRYLCDRMYPHDNWLISFRFQHILVGLVLPGLIILTCYCIIISKLSHSKGHQK
RKALKTTVILILTFFACWLPYYIGISIDTFILLGVIRHRCSLDTIVHKWISITEALAFFH
CCLNPILYAFLGAKFKTSAQNALTSVSRGSSLKILSKSKRGGHSSVSTESESSSFHSS
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12433920 | 12089144

Coupling with G-proteins:
Family:Gi/o REFERENCES:8629022
1GPR0217Galpha-i1-Gallus gallus
2GPR0225Galpha-i2-Gallus gallus


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory