gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0070 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY 5-HYDROXYTRYPTAMINE RECEPTOR
SUBFAMILY 5-HT-2A

Cross References:
UniProt P28223 | Q5T8C0 EMBL X57830 | S42168 | S42165 | S42167 | S71229 | AF498982 | AL160397 | AL136958 | AL136958 | AL160397 | BC069356 | BC069576 | BC074848 | BC074849 | BC096839 | M86841 | S50130 | S49737 | S50113
InterPro IPR000455 | IPR002231 | IPR000276 GPCRDB 5HT2A_HUMAN
GENEID 3356 MIM 182135
PRINTS PR00516 | PR01101 | PR00237 PFAM PF00001

Details:
NAME 5-HYDROXYTRYPTAMINE RECEPTOR_5-HT-2A_Homo sapiens
DESCRIPTION 5-hydroxytryptamine receptor 2A (5-HT-2A) (Serotonin receptor 2A) (5-HT-2).
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
GENE HTR2A | HTR2
SEQUENCE
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGC
LSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIH
REPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGA
LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYK
SSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
FRAGMENT NO

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Scaffold:
TYPE JAK2( Janus kinase) REFERENCES 9169451
TYPE MUPP1( multiple activated protein kinase 1) REFERENCES 11150294
TYPE PSD95( postsynaptic density protein) REFERENCES 12682061

Coupling with G-proteins:
Family:Gq/11 REFERENCES:1765383
1GPR0002Galpha-q-Homo sapiens-2
2GPR0029Galpha-11-Homo sapiens
3GPR0237Galpha-q-Homo sapiens-1


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory