gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0711 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY CHEMOTACTIC PEPTIDE RECEPTOR
SUBFAMILY C5A

Cross References:
UniProt Q9P296 EMBL AB038237 | AF317655 | AY268430 | BC067478
InterPro IPR001274 | IPR000276 GPCRDB C5ARL_HUMAN
GENEID 27202 MIM 609949
PRINTS PR00426 | PR00237 PFAM PF00001

Details:
NAME CHEMOTACTIC PEPTIDE RECEPTOR_C5A_Homo sapiens-1
DESCRIPTION C5a anaphylatoxin chemotactic receptor C5L2 (G-protein coupledreceptor 77).
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
GENE GPR77 | C5L2
SEQUENCE 
MGNDSVSYEYGDYSDLSDRPVDCLDGACLAIDPLRVAPLPLYAAIFLVGVPGNAMVAWVA
GKVARRRVGATWLLHLAVADLLCCLSLPILAVPIARGGHWPYGAVGCRALPSIILLTMYA
SVLLLAALSADLCFLALGPAWWSTVQRACGVQVACGAAWTLALLLTVPSAIYRRLHQEHF
PARLQCVVDYGGSSSTENAVTAIRFLFGFLGPLVAVASCHSALLCWAARRCRPLGTAIVV
GFFVCWAPYHLLGLVLTVAAPNSALLARALRAEPLIVGLALAHSCLNPMLFLYFGRAQLR
RSLPAACHWALRESQGQDESVDSKKSTSHDLVSEMEV
 FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Fluorescence Resonance Energy Transfer (FRET) REFERENCES 12835318

Coupling with G-proteins:
Family:Gq/11 REFERENCES:7870028
1GPR0043Galpha-16-Homo sapiens
Family:Gi/o REFERENCES:7887933
2GPR0020Galpha-o1-Homo sapiens
3GPR0109Galpha-i3-Homo sapiens
4GPR0218Galpha-i1-Homo sapiens-1
5GPR0226Galpha-i2-Homo sapiens-2
6GPR0261Galpha-i1-Homo sapiens-2
7GPR0334Galpha-o-Homo sapiens
8GPR0365Galpha-i2-Homo sapiens-1
9GPR0128Galpha-z-Homo sapiens-2
10GPR0327Galpha-z-Homo sapiens-3
11GPR0333Galpha-z-Homo sapiens-1

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athina University of Athens
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 Dept. of Cell Biology and Biophysics
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