| Details: |
| NAME |
DOPAMINE RECEPTOR_D2_Mus musculus |
| DESCRIPTION |
D(2) dopamine receptor (Dopamine D2 receptor). |
| SPECIES |
Mus musculus |
COMMON NAME |
Mouse |
NCBI Taxonomy |
10090 |
| GENE |
Drd2 |
| SEQUENCE |
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMS
RRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNS
AVNPIIYTTFNIEFRKAFMKILHC
|
FRAGMENT |
NO
|
|
|
|
|
Homepage
|
| Dimerization: |
| HOMODIMER INFORMATION |
There is experimental evidence for homo-dimerization
|
METHOD |
Fluorescence Resonance Energy Transfer (FRET)
|
REFERENCES |
11682068
|
| HOMODIMER INFORMATION |
There is experimental evidence for homo-dimerization
|
METHOD |
Immunoprecipitation
|
REFERENCES |
10860933
|
| HETERODIMER INFORMATION |
Forms heterodimers with Dopamine D3 Receptors. Dimerization results in an Increased affnity and potency for agonists and antagonists
|
METHOD |
Functional reconstitution
|
REFERENCES |
11373283
|
| HETERODIMER INFORMATION |
Forms heterodimer with Somatostatin SST5 Receptor. Dimerization results in increased ligand binding affnity and enhanced signalling
|
METHOD |
Photobleaching Fluorescence Resonance Energy Transfer (FRET)
|
REFERENCES |
10753124
|
| HETERODIMER INFORMATION |
Forms heterodimers with Adenosine A2A Receptor. Heterodimerization results in co-desensitization and co-internalization of the receptors
|
METHOD |
Immunoprecipitation
|
REFERENCES |
11872740
|
| Scaffold: |
| TYPE |
alpha-filamin/ABP280( actin binding protein 280)
|
REFERENCES |
11911837 | 1239393
|
| TYPE |
Protein 4.1N
|
REFERENCES |
12181426
|
| TYPE |
Spinophilin/neurabin II
|
REFERENCES |
10391935
|
| Coupling with G-proteins: |
| Family:Gi/o |
REFERENCES: | 2974511 | | 1 | GPR0021 | Galpha-o1-Mus musculus | | 2 | GPR0227 | Galpha-i2-Mus musculus-2 | | 3 | GPR0289 | Galpha-i1-Mus musculus | | 4 | GPR0331 | Galpha-i2-Mus musculus-1 | | 5 | GPR0385 | Galpha-i3-Mus musculus |
|
biol.uoa.gr
for comments, corrections and
data (sequence) submission.
