gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0792 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY DOPAMINE RECEPTOR
SUBFAMILY D3

Cross References:
UniProt Q13167 EMBL U25441
InterPro IPR001620 | IPR000929 | IPR000276 GPCRDB Q13167_HUMAN
PRINTS PR00568 | PR00242 | PR00237 PFAM PF00001

Details:
NAME DOPAMINE RECEPTOR_D3_Homo sapiens-1
DESCRIPTION Dopamine D3 receptor.
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
GENE DRD3
SEQUENCE
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLLCMAVLKERAL
QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSICCDVFVTLDVMMCTASILNL
CAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGNPTVC
SISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQ
TLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKL
SNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGTFIVCWLPFFLTHVLNTHCQTCHVS
PELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation REFERENCES 9361002 | 10999936 | 11039730
HETERODIMER INFORMATION Forms heterodimers with Dopamine D2 Receptors. Dimerization results in an Increased affnity and potency for agonists and antagonists METHOD Functional reconstitution REFERENCES 11373283

Scaffold:
TYPE alpha-filamin/ABP280( actin binding protein 280) REFERENCES 11911837 | 1239393
TYPE Nck, Grb2 REFERENCES 9843378 | 11384839

Coupling with G-proteins:
Family:Gi/o REFERENCES:1975644
1GPR0020Galpha-o1-Homo sapiens
2GPR0109Galpha-i3-Homo sapiens
3GPR0218Galpha-i1-Homo sapiens-1
4GPR0226Galpha-i2-Homo sapiens-2
5GPR0261Galpha-i1-Homo sapiens-2
6GPR0334Galpha-o-Homo sapiens
7GPR0365Galpha-i2-Homo sapiens-1


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory