gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0867 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY GLYCOPROTEIN HORMONE RECEPTOR
SUBFAMILY LSH RECEPTOR

Cross References:
UniProt Q90674 EMBL U31987
InterPro IPR000276 | IPR002131 GPCRDB LSHR_CHICK
PRINTS PR00373 | PR00237 PFAM PF00001

Details:
NAME GLYCOPROTEIN HORMONE RECEPTOR_LSH RECEPTOR_Gallus gallus
DESCRIPTION Lutropin-choriogonadotropic hormone receptor .
SPECIES Gallus gallus COMMON NAME Chicken NCBI Taxonomy 9031
GENE LHCGR
SEQUENCE
PKILTCTPEPDAFNPCEDILGYSFLRVLIWFINILALAGNFIVLLVLITSHYKLTVPRFL
MCNLSFADFCMGLYLLLIASVDAQTSGQYYNHAIDWQTGSGCSTAGFFTVFASELSVYTL
TVITIERWHTITYAMQLDRKLRLRHAVPIMLGGWVFSILIAVLPLLGVSSYMKVSICLPM
DIETGLSQAYILLILMLNVIAFLVICACYIKIYVAVQNPELVAANKDTKIAKRMAILIFT
DFTCMAPISFFAISAAIKVPLITVTNSKILLVLFYPVNSCANPFLYAIFTKAFQRDFFLL
MSKLGCCKSRAELYRVNYFSAYTPNCKNGSSAPGPSKASQALLLLSASEKLCKTRRSTKK
SQPECQ
FRAGMENT YES

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Photobleaching Fluorescence Resonance Energy Transfer (FRET) REFERENCES 11108263

Scaffold:
TYPE GIPC( GAIP-interacting protein) REFERENCES 14507927
TYPE NHERF1( Na+/H+ exchange regulatory factor) /EBP50( ezrin-radixin-moesin binding phosphoprotein 50-kD protein) REFERENCES 14507927
TYPE p38JAB1 REFERENCES 10788448

Coupling with G-proteins:
Family:Gi/o REFERENCES:1516719
1GPR0217Galpha-i1-Gallus gallus
2GPR0225Galpha-i2-Gallus gallus
Family:Gq/11 REFERENCES:1516719
3GPR0003Galpha-11-Gallus gallus


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athina University of Athens
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Biophysics
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Laboratory