gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0884 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY GLYCOPROTEIN HORMONE RECEPTOR
SUBFAMILY TSH RECEPTOR

Cross References:
UniProt Q8SPP9 | Q9BG55 | Q9BG56 EMBL AY082015 | AF338249 | AF338250
InterPro IPR000276 | IPR002131 | IPR002274 GPCRDB TSHR_PIG
GENEID 397560
PRINTS PR00373 | PR00237 | PR01145 PFAM PF00001

Details:
NAME GLYCOPROTEIN HORMONE RECEPTOR_TSH RECEPTOR_Sus scrofa-2
DESCRIPTION Thyrotropin receptor precursor (TSH-R) (Thyroid-stimulating hormonereceptor).
SPECIES Sus scrofa COMMON NAME Pig NCBI Taxonomy 9823
GENE TSHR
SEQUENCE
MSLTPLLQLALLLALPRSLRGKGCPSPPCECHQEDDFRVTCKDIHSIPPLPPNTQTLKFI
ETHLKTIPSRAFSNLPNISRIYLSIDATLQQLESQSFYNLSKMTHIEIRNTRSLTYINPG
ALKDLPLLKFLGIFNTGLRIFPDLTKVYSTDVFFILEITDNPYMTSIPANAFQGLCNETL
TLKLYNNGFTSVQGHAFNGTKLDAVYLNKNKYLTVIDKDAFGGVFSGPTLLDVSYTSVTA
LPPKGLEHLKELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLM
CNESSIRSLRQRKSVNAVNGPFYQEYEEDLGDSSVGNKENSKFQDTHSNSHYYVFFEEQE
DEIIGFGQELKNPQEETLQAFDSHYDYTVCGGSEDMVCTPKSDEFNPCEDIMGYRFLRIV
VWFVSLLALLGNVFVLVILLTSHYKLTVPRFLMCNLAFADFCMGMYLLLIASVDLYTQSE
YYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHAYA
IMAGGWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIILVLLLNIVAFTIVCSC
YVKIYITVRNPQYNPGDKDTKIAKRMAVLIFTDFMCMAPISFYALSALMNKPLITVTNSK
ILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGFCKRQAQAYRGQRVSPKNSTGIQ
VQKVTQNMRQSLPNMQDDYELLENSHLTHKKHDQISKEYKQPVL
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Fluorescence Resonance Energy Transfer (FRET) REFERENCES 12223484

Coupling with G-proteins:
Family:Gs REFERENCES:8552586
1GPR0125Galpha-s-Sus scrofa


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory