gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0885 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY GLYCOPROTEIN HORMONE RECEPTOR
SUBFAMILY TSH RECEPTOR

Cross References:
UniProt Q98TF4 EMBL AB047390
InterPro IPR000276 | IPR002131 | IPR002274 GPCRDB Q98TF4_ORENI
PRINTS PR00373 | PR00237 | PR01145 PFAM PF00001

Details:
NAME GLYCOPROTEIN HORMONE RECEPTOR_TSH RECEPTOR_Oreochromis niloticus
DESCRIPTION Thyrotropin receptor.
SPECIES Oreochromis niloticus COMMON NAME Nile tilapia NCBI Taxonomy 8128
GENE tTSH-R
SEQUENCE
MQVITCALFTLVTLPISTASEADSCPAVCECSEWKTLTISCFDIDILPRFPPSTETLWLF
ETRLSSVPADAFASVVNISRIYISVDTTLQRLEKHSFYSLRKITHIEIRNAKSLTYIDPE
AFKHLPELKYLGIFNTGLTFFPDLSNIHSNDMNFILEIVDHPYITEIPANSFRGITSEAL
TVMLYGNGFRSVRHHAFNGTKLDQVDLHRNKYLTEMDDGCFVGTISGPILLDVSQTGITS
LPSTGMDSVRELKARDAWALKKLPPIKTFKHLTVANLTYPSHCCGFKNLKKKRGFLEYII
CNLTALYDQHQKRSVGPLRMPSLQGDGVVETLPDRELKDGGHRESQQDWKSGDFHGSLHY
HAYFGGHPDEDVGFGETLKNPQEDNSQEFDSRYDYVVCEEGEEVACAPAPDEFNPCEDIM
GFGFLRVSVWFVSLLAVLGNVVVLLVLLTSHYKLSVSRFLMCHLAFADLCMGIYLLLIAS
VDLHTRAEYFNHAIDWQTGPGCGLAGFFTVFASELSVYTLTAITLERWYAITFAMRLDRK
LHLHHAAAVMLGGWVFCILLALLPLVGVSSYQKVSICLPMDTESTAAQIYIMSVLVLNIL
AFFIICACYFKIYCTVHNPHYHSGSKDTNIAKRMAVLIFTDFLCMAPISFYAISAVLDRP
LITVSNSKILLVLFYPLNSCANPFLYAIFTKAFRGDIFILLSKVGLCQQRAQLFRGQTVS
SKGSSGTSQIRRDKDKSRKGGSIGQEEVPIHLKRSAGHTYHPAIGQQKNPEESQRLDT
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Fluorescence Resonance Energy Transfer (FRET) REFERENCES 12223484

Coupling with G-proteins:
No information


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory