Photo Fotis Baltoumas

PhD Student
fbaltoumasbiol.uoa.gr

EDUCATION
2014 - present: Faculty of Biology, University of Athens, PhD in Bioinformatics, entitled "Computational studies of Protein-Protein Interactions in Transmembrane Proteins".
(Supervisor: Prof. S.J. Hamodrakas)

2014 - 2015: MSc in Bioinformatics, Faculty of Biology, University of Athens
Thesis Title: "Computational Studies of Oligomeric Interactions in G-protein coupled Receptors" (Supervisor: Prof. S.J. Hamodrakas)

2006 - 2014: BSc in Biology, Faculty of Biology, University of Athens
Thesis Title: "Studies of Interactions between GPCRs, G-proteins and Effectors" (Supervisor: Prof. S.J. Hamodrakas)


RESEARCH INTERESTS
My research interests are focused in the fields of Computational Biology and Structural Bioinformatics for exploring the structural, dynamic and functional features of biological membranes and membrane-bound proteins. At the same time, I am interested in exploring the structural dynamic features that govern peptide and protein aggregation through computational means. Towards this end, I employ a number of Computational Biophysics methods including Macromolecular Modeling and Docking, Molecular Mechanics calculations and Molecular Dynamics simulations, as well as Computational Biology analysis methods such as biological networks.

PUBLICATIONS Search in
Louros N.N., Tsiolaki P.L, Baltoumas F.A., Chryssikos G.D., Gionis V., Hamodrakas S.J., Iconomidou V.A. (2017) Tracking the amyloidogenic core of IAPP amyloid fibrils: Insights from micro-Raman spectroscopy. J. Struct. Biol. Aug;199(2):140-152 [Epub ahead of print] [Abstract] [PDF] doi: 10.1016/j.jsb.2017.06.002.
Baltoumas, F.A., Theodoropoulou, M.C., Hamodrakas, S.J. (2016) Molecular dynamics simulations and structure-based network analysis reveal structural and functional aspects of G-protein coupled receptor dimer interactions. J. Comput. Aided. Mol. Des. Jun;30(6):489-512. [Abstract] [PDF] doi: 10.1007/s10822-016-9919-y.
Louros, N.N., Baltoumas, F.A., Hamodrakas, S.J., Iconomidou, V.A. (2016) A beta-solenoid model of the Pmel17 repeat domain: insights to the formation of functional amyloid fibrils. J. Comput. Aided. Mol. Des. Feb;30(2):153-64. [Abstract] [PDF] doi: 10.1007/s10822-015-9892-x.
Baltoumas, F.A., Theodoropoulou, M.C., Hamodrakas, S.J. (2013) Interactions of the alpha-subunits of heterotrimeric G-proteins with GPCRs, effectors and RGS proteins: A critical review and analysis of interacting surfaces, conformational shifts, structural diversity and electrostatic potentials. Journal of Structural Biology, 182 (2013) 209-218. [Abstract] [PDF][Supplement]