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Dr. Fotis
Baltoumasfbaltoumas biol.uoa.gr |
| EDUCATION | |
| 2014 - 2019: Faculty of Biology, University of Athens, PhD in Bioinformatics, entitled "Computational
studies of Protein-Protein Interactions in Transmembrane Proteins".
(Supervisor: Prof. S.J. Hamodrakas)
2014 - 2015: MSc in Bioinformatics, Faculty of Biology, University of Athens Thesis Title: "Computational Studies of Oligomeric Interactions in G-protein coupled Receptors" (Supervisor: Prof. S.J. Hamodrakas)2006 - 2014: BSc in Biology, Faculty of Biology, University of Athens Thesis Title: "Studies of Interactions between GPCRs, G-proteins and Effectors" (Supervisor: Prof. S.J. Hamodrakas) | |
| RESEARCH INTERESTS | |
| My research interests are focused in the fields of Computational Biology and Structural Bioinformatics for exploring the structural, dynamic and functional features of biological membranes and membrane-bound proteins. At the same time, I am interested in exploring the structural dynamic features that govern peptide and protein aggregation through computational means. Towards this end, I employ a number of Computational Biophysics methods including Macromolecular Modeling and Docking, Molecular Mechanics calculations and Molecular Dynamics simulations, as well as Computational Biology analysis methods such as biological networks. | |
| PUBLICATIONS |
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| Baltoumas, F.A., Hamodrakas, S.J., Iconomidou V.A. (2019) The Gram-Negative Outer Membrane Modeler: automated building of lipopolysaccharide-rich bacterial outer membranes in four force fields J. Comput. Chem. Jul 5; 40(18): 1727-1734 [Epub ahead of print] [Abstract] [Full Text] doi:10.1002/jcc.25823. | |
| Tsiolaki, P.L., Katsafana, A.D., Baltoumas, F.A., Louros, N.N., Iconomidou, V.A. (2019) Hidden Aggregation Hot-Spots on Human Apolipoprotein E: A Structural Study. Int. J. Mol. Sci. 20(9):E2274. [Abstract] [Full Text] doi:10.3390/ijms20092274. | |
| Triantaphyllopoulos, K.A., Baltoumas, F.A., Hamodrakas S.J. (2019) Structural characterization and molecular dynamics simulations of the caprine and bovine solute carrier family 11 A1 (SLC11A1). J. Comput. Aid. Mol. Des. Feb; 33(2):265-285 [Epub ahead of print] [Abstract] [Full Text] doi:10.1007/s10822-018-0179-x. | |
| Tsiolaki, P.L., Nasi, G.I., Baltoumas, F.A., Louros N.N., Magafa, V., Hamodrakas S.J., Iconomidou V.A. (2018) αCGRP, another amyloidogenic member of the CGRP family. J. Struct. Biol. Jul;203(1):27-36 [Epub ahead of print] [Abstract] [PDF] doi:10.1016/j.jsb.2018.02.008. | |
| Louros N.N., Tsiolaki P.L, Baltoumas F.A., Chryssikos G.D., Gionis V., Hamodrakas S.J., Iconomidou V.A. (2017) Tracking the amyloidogenic core of IAPP amyloid fibrils: Insights from micro-Raman spectroscopy. J. Struct. Biol. Aug;199(2):140-152 [Epub ahead of print] [Abstract] [PDF] doi: 10.1016/j.jsb.2017.06.002. | |
| Baltoumas, F.A., Theodoropoulou, M.C., Hamodrakas, S.J. (2016) Molecular dynamics simulations and structure-based network analysis reveal structural and functional aspects of G-protein coupled receptor dimer interactions. J. Comput. Aided. Mol. Des. Jun;30(6):489-512. [Abstract] [PDF] doi: 10.1007/s10822-016-9919-y. | |
| Louros, N.N., Baltoumas, F.A., Hamodrakas, S.J., Iconomidou, V.A. (2016) A beta-solenoid model of the Pmel17 repeat domain: insights to the formation of functional amyloid fibrils. J. Comput. Aided. Mol. Des. Feb;30(2):153-64. [Abstract] [PDF] doi: 10.1007/s10822-015-9892-x. | |
| Baltoumas, F.A., Theodoropoulou, M.C., Hamodrakas, S.J. (2013) Interactions of the alpha-subunits of heterotrimeric G-proteins with GPCRs, effectors and RGS proteins: A critical review and analysis of interacting surfaces, conformational shifts, structural diversity and electrostatic potentials. Journal of Structural Biology, 182 (2013) 209-218. [Abstract] [PDF][Supplement] | |