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Dr. Nikolaos Lourosnlouros biol.uoa.gr |
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EDUCATION |
| 2011-2016 : Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens,Ph.D in Biophysics/Structural Biology, entitled "Structural studies of 'aggregation-prone' peptide-analogues of proteins implicated with amyloidosis diseases and for the formation of functional protective amyloids". (Supervisor : Prof. S. J. Hamodrakas)
2012-2014 : M.Sc in Bioinformatics, Faculty of Biology, University of Athens
Thesis Title: "Structural studies regarding sequence repeats of amyloidogenic proteins".(Supervisor : Prof. S. J. Hamodrakas)
2006-2011 : B.Sc in Biology, Faculty of Biology, University of Athens
Diploma Thesis: "Biophysical studies of peptide-analogues of zona pellucida proteins with amyloidogenic properties".(Supervisor : Prof. S. J. Hamodrakas)
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| RESEARCH INTERESTS |
| My scientific research interests are currently focused in the fields of Structural Biology/Molecular Biophysics and Structural Bioinformatics/Computational Biology. More specifically:
1. Structural studies of "aggregation-prone" peptide-analogues of proteins involved in the formation of functional amyloids.
2. Structural studies of "aggregation-prone" peptide-analogues of proteins associated with conformational diseases/amyloidoses.
3. Computational and structural analysis of repetitive sequences.
4. Protein structure determination by comparative modeling techniques.
5. Protein Folding/Protein-protein Interactions.
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| PUBLICATIONS |
Search in  |
| Tsiolaki, P.L., Louros N.N., Iconomidou V.A. (2018) Hexapeptide Tandem Repeats Dictate the
Formation
of Silkmoth Chorion, a Natural Protective Amyloid. J. Mol. Biol. 430 (20): 3774-3783.
[Abstract] [PDF]
doi:10.1016/j.jmb.2018.06.042.
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| Tsiolaki, P.L., Nasi, G.I., Baltoumas, F.A., Louros N.N., Magafa, V., Hamodrakas S.J.,
Iconomidou V.A. (2018) αCGRP, another amyloidogenic member of the CGRP family. J. Struct. Biol. Jul;203(1):27-36 [Epub ahead of print]
[Abstract] [PDF]
doi:10.1016/j.jsb.2018.02.008.
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| Louros N.N., Tsiolaki P.L, Baltoumas F.A., Chryssikos G.D., Gionis V., Hamodrakas S.J.,
Iconomidou V.A.
(2017) Tracking the amyloidogenic core of IAPP amyloid fibrils: Insights from micro-Raman spectroscopy. J. Struct. Biol. Aug;199(2):140-152 [Epub ahead of
print]
[Abstract] [PDF] doi:
10.1016/j.jsb.2017.06.002.
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| Tsiolaki, P.L., Louros, N.N., Zompra, A.A.,Hamodrakas, S.J., Iconomidou, V.A. (2016)
Unraveling the aggregation propensity of human insulin C-peptide. Biopolymers. 2016 Jun 3. [Epub ahead of print]
[Abstract] [PDF] doi: 10.1002/bip.22882.
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| Louros, N.N., Bolas, G.M., Tsiolaki, P.L., Hamodrakas, S.J., Iconomidou, V.A. (2016)
Intrinsic Aggregation Propensity of the CsgB Nucleator Protein is Crucial for Curli Fiber Formation. J. Struct. Biol. Aug;195(2):179-89. Epub 2016 May 28.
[Abstract] [PDF] doi: 10.1016/j.jsb.2016.05.012.
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| Louros, N.N., Baltoumas, F.A., Hamodrakas, S.J., Iconomidou, V.A. (2016) A beta-solenoid model of the Pmel17 repeat domain: insights to the formation of functional amyloid fibrils. J. Comput. Aided. Mol. Des. Feb;30(2):153-64.
[Abstract] [PDF] doi: 10.1007/s10822-015-9892-x.
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| Louros, N.N., Chrysina, E.D., Baltatzis, G.E., Patsouris, E.S., Hamodrakas, S.J., Iconomidou, V.A. (2016) A common "aggregation-prone" interface possibly participates in the self-assembly of human zona pellucida proteins. FEBS Letters, 590: 619-630.
[Abstract]
[PDF]doi: 10.1002/1873-3468.12099.
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| Louros, N.N., Iconomidou, V.A. (2016) Identification of an amyloid fibril forming segment of human Pmel17 repeat domain (RPT domain). Biopolymers. 2016 Jan;106(1):133-9.
[Abstract]
[PDF] doi: 10.1002/bip.22746.
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| Tsiolaki, P.L., Louros, N.N., Hamodrakas, S.J., Iconomidou, V.A. (2015) Exploring the 'aggregation-prone' core of human Cystatin C: A structural study. J. Struct. Biol. Sep;191(3):272-80. Epub 2015 Jul 31.
[Abstract]
[PDF] doi: 10.1016/j.jsb.2015.07.013
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| Louros, N.N., Tsiolaki, P.L., Griffin, M.D., Howlett, G.J., Hamodrakas, S.J., Iconomidou, V.A. (2015) Chameleon 'aggregation-prone' segments of apoA-I: A model of amyloid fibrils formed in apoA-I amyloidosis. Int. J. Biol. Macromol. Volume 79, pp. 711-718, August 2015.
[Abstract]
[PDF] doi: 10.1016/j.ijbiomac.2015.05.032
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| Louros, N.N., Tsiolaki, P.L., Zompra, A.A., Pappa, E.V., Magafa, V., Pairas, G., Cordopatis, P., Cheimonidou, C., Trougakos, I.P., Iconomidou, V.A., Hamodrakas, S.J.(2015) Structural Studies and Cytotoxicity Assays of "Aggregation-Prone" IAPP8-16 and its Non-Amyloidogenic Variants Suggest its Important Role in Fibrillogenesis and Cytotoxicity of Human Amylin (hIAPP). Biopolymers Volume 104, Issue 3, pp. 196-205, May 2015.[Abstract]
[PDF] doi: 10.1002/bip.22650 |
| Louros, N.N., Petronikolou N., Karamanos T., Cordopatis P., Iconomidou, V.A., Hamodrakas, S.J. (2014) Structural studies of 'aggregation-prone' peptide-analogues of teleostean egg chorion ZPB proteins. Biopolymers [Abstract]
[PDF] doi: 10.1002/bip.22563 |
| Louros, N.N., Iconomidou, V.A., Tsiolaki, P.L., Chrysina, E.D., Baltatzis, G.E., Patsouris, E.S., Hamodrakas, S.J.(2014) An N-terminal pro-atrial natriuretic peptide (NT-proANP) 'aggregation-prone' segment involved in isolated atrial amyloidosis. FEBS Lett., 588: 52-57.
[Abstract]
[PDF] doi: 10.1016/j.febslet.2013.10.049
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| Louros, N.N., Iconomidou, V.A., Giannelou, P., Hamodrakas, S.J. (2013) Structural Analysis of Peptide-Analogues of Human Zona Pellucida ZP1 Protein with Amyloidogenic Properties: Insights into Mammalian Zona Pellucida Formation. PLoS ONE 8(9): e73258.
[Abstract]
[PDF] doi: 10.1371/journal.pone.0073258
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