gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::Effector View
Entry 1 of 1 :: EFF0364 ::
FAMILY Ser Thr protein kinases
SUBFAMILY G protein coupled receptor kinases
TYPE GRK3

Cross References:
UniProt P26819 EMBL M87855
InterPro IPR015743 | IPR000239 | IPR001849 | IPR011993 | IPR000961 | IPR000719 | IPR000342 | IPR008271 | IPR002290
PRODOM PD000001 GENEID 25372
PRINTS PR00717 PFAM PF00169 | PF00069 | PF00615

Details:
NAME GRK3-Rattus norvegicus
DESCRIPTION Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G-protein-coupled receptor kinase 3).
SPECIES Rattus norvegicus COMMON NAME Rat NCBI Taxonomy 10116
GENE Adrbk2 | Grk3
SEQUENCE 
MADLEAVLADVSYLMAMEKSKATPAARASKKVVLPEPSIRSVMQRYLAERNEITFDKIFN
QKIGFLLFKDFCLNEIGEAVPQVKFYEEIKEYEKLDNEEDRLHRSRQMYDAYIMRELLSS
THQFSKQAVEHVQSHLSKKQVTPTLFQPYIEEICESLRGDIFQKFMESEKFTRFCQWKNV
ELNIHLSMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRVKMKQGETLALNER
IMLSLVSTGDCPFIV
 FRAGMENT NO
FUNCTION Specifically phosphorylates the agonist-occupied form ofs the beta-adrenergic and closely related receptors
Interacting with G-proteins:
Family:Gq/11 REFERENCES:15251227 | 14654303 | 16182515
1GPR0032Galpha-11-Rattus norvegicus
2GPR0242Galpha-q-Rattus norvegicus
Family:Gbeta REFERENCES:15251227 | 14654303
3GPR0149Gbeta-1-Rattus norvegicus-2
4GPR0157Gbeta-2-Rattus norvegicus-2
5GPR0162Gbeta-3-Rattus norvegicus
6GPR0166Gbeta-4-Rattus norvegicus
7GPR0169Gbeta-5-Rattus norvegicus
8GPR0396Gbeta-2-Rattus norvegicus-1
9GPR0397Gbeta-1-Rattus norvegicus-1
Family:Ggamma REFERENCES:15251227 | 14654303
10GPR0190Ggamma-5-Rattus norvegicus
11GPR0194Ggamma-7-Rattus norvegicus
12GPR0197Ggamma-8-Rattus norvegicus
13GPR0201Ggamma-11-Rattus norvegicus
14GPR0256Ggamma-2-Rattus norvegicus
15GPR0257Ggamma-3-Rattus norvegicus
16GPR0258Ggamma-4-Rattus norvegicus
17GPR0259Ggamma-10-Rattus norvegicus
18GPR0260Ggamma-12-Rattus norvegicus

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