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gpDB::G-protein View
Entry 1 of 1 :: GPR0242 ::
CLASS Galpha
FAMILY Gq/11
SUBFAMILY Galpha-q
TYPE Galpha-q

Cross References:
UniProt P82471 EMBL AF234260 | L37294
InterPro IPR001019 | IPR000654 | IPR011025
PRODOM PD000281
GENEID 81666
PRINTS PR00318 | PR00442 PFAM PF00503

Details:
NAME Galpha-q-Rattus norvegicus
DESCRIPTION Guanine nucleotide-binding protein G(q) subunit alpha (Guaninenucleotide-binding protein alpha-q).
SPECIES Rattus norvegicus COMMON NAME Rat NCBI Taxonomy 10116
POST TRANSLATION MODIFICATIONS null GENE Gnaq
SEQUENCE 
MACCLSEEAKEARRINDEIERQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSG
YSDEDKRGFTKLVYQNIFTAMQAMVRAMDTLKIPYKYEHNKAHAQLVREVDVEKVSAFEN
PYVDAIKSLWNDPGIQECYDRRREYQLSDSTKYYLNDLDRVADPSYLPTQQDVLRVRVPT
TGIIEYPFDLQSVIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNEN
RMEESKALFRTIITYPWFQNSSVILFLNKKDLLEEKIMYSHLVDYFPEYDGPQRDAQAAR
EFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV
 FRAGMENT NO
FUNCTION Guanine nucleotide-binding proteins (G proteins) ares involved as modulators or transducers in various transmembranes signaling systems
Effectors:
1EFF0128Burton's tyrosine kinase-Rattus norvegicusStimulation (indirect stimulation of p38 MAPK)15251227 | 9305846 | 16182515
2EFF0294Caveolin-1-Rattus norvegicus-1Gq Binds Caveolin to Concentrate in Caveolae16182515 | 11251080
3EFF0295Caveolin-1-Rattus norvegicus-2Gq Binds Caveolin to Concentrate in Caveolae16182515 | 11251080
4EFF0296Caveolin-1-Rattus norvegicus-3Gq Binds Caveolin to Concentrate in Caveolae16182515 | 11251080
5EFF0339EBP50/NHERF-1-Rattus norvegicusInhibits PLC-beta activation and blocks Gqa-induce Tph and CXCR4 receptor internalization16182515
6EFF0356GRK2-Rattus norvegicusInhibits PLC-beta activation and blocks Gqa-mediated GLUT4 translocation and glucose uptake in 3T3 adipocytes15251227 | 14654303 | 16182515
7EFF0364GRK3-Rattus norvegicusStimulation15251227 | 14654303 | 16182515
8EFF0403Kir 3.1(GIRK1)-Rattus norvegicus-1Inhibition12661754
9EFF0404Kir 3.1(GIRK1)-Rattus norvegicus-2Inhibition12661754
10EFF0405Kir 3.1(GIRK1)-Rattus norvegicus-3Inhibition12661754
11EFF0416Kir 3.2(GIRK2)-Rattus norvegicus-1Inhibition12661754
12EFF0417Kir 3.2(GIRK2)-Rattus norvegicus-2Inhibition12661754
13EFF0418Kir 3.2(GIRK2)-Rattus norvegicus-3Inhibition12661754
14EFF0419Kir 3.2(GIRK2)-Rattus norvegicus-4Inhibition12661754
15EFF0423Kir 3.3(GIRK3)-Rattus norvegicusInhibition12661754
16EFF0431Kir 3.4(GIRK4)-Rattus norvegicusInhibition12661754
17EFF0440LARG RhoGEF-Rattus norvegicusStimulation (indirect activation of Rho)15251227 | 12024019
18EFF0452PDZ RhoGEF-Rattus norvegicusNo data1525227 | 16182515
19EFF0528Phospholipase C beta-1-Rattus norvegicusStimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
20EFF0538Phospholipase C beta-2-Rattus norvegicus-1Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
21EFF0539Phospholipase C beta-2-Rattus norvegicus-2Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
22EFF0552Phospholipase C beta-3-Rattus norvegicus-1Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
23EFF0553Phospholipase C beta-3-Rattus norvegicus-2Stimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
24EFF0569Phospholipase C beta-4-Rattus norvegicusStimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
25EFF0574PI3K alpha-Rattus norvegicus-1Inhibition of PI3K kinase activity in vitro16182515
26EFF0575PI3K alpha-Rattus norvegicus-2Inhibition of PI3K kinase activity in vitro16182515
27EFF0584PI3K beta-Rattus norvegicusInhibition of PI3K kinase activity in vitro16182515
28EFF0875Synembryn(Ric8a)-Rattus norvegicusStimulates Gqa activation and steady-state GTPase activity in vitro16182515 | 12509430
29EFF0881TRP repeat protein-1-Rattus norvegicusG16a co-expression enhances TPR1 interaction with Ras16182515 | 12748287
30EFF1336Tubulin-Rattus norvegicus-10Potentiates receptor-induced PLC-beta activation16182515
31EFF1337Tubulin-Rattus norvegicus-11Potentiates receptor-induced PLC-beta activation16182515
32EFF1338Tubulin-Rattus norvegicus-12Potentiates receptor-induced PLC-beta activation16182515
33EFF1339Tubulin-Rattus norvegicus-2Potentiates receptor-induced PLC-beta activation16182515
34EFF1340Tubulin-Rattus norvegicus-1Potentiates receptor-induced PLC-beta activation16182515
35EFF1342Tubulin-Rattus norvegicus-3Potentiates receptor-induced PLC-beta activation16182515
36EFF1343Tubulin-Rattus norvegicus-4Potentiates receptor-induced PLC-beta activation16182515
37EFF1344Tubulin-Rattus norvegicus-5Potentiates receptor-induced PLC-beta activation16182515
38EFF1345Tubulin-Rattus norvegicus-6Potentiates receptor-induced PLC-beta activation16182515
39EFF1346Tubulin-Rattus norvegicus-7Potentiates receptor-induced PLC-beta activation16182515
40EFF1347Tubulin-Rattus norvegicus-8Potentiates receptor-induced PLC-beta activation16182515
41EFF1348Tubulin-Rattus norvegicus-9Potentiates receptor-induced PLC-beta activation16182515

Coupling with GPCRs:
1GPCR00715-HYDROXYTRYPTAMINE RECEPTOR_5-HT-2A_Rattus norvegicus1765383
2GPCR00815-HYDROXYTRYPTAMINE RECEPTOR_5-HT-2B_Rattus norvegicus8786115
3GPCR00865-HYDROXYTRYPTAMINE RECEPTOR_5-HT-2C_Rattus norvegicus1302605
4GPCR0206ADRENOCEPTOR (A1-ADRENOCEPTOR)_A1A(Adrenoceptor)_Rattus norvegicus8396931
5GPCR0222ADRENOCEPTOR (A1-ADRENOCEPTOR)_A1B(Adrenoceptor)_Rattus norvegicus1662393
6GPCR0225ADRENOCEPTOR (A1-ADRENOCEPTOR)_A1D(Adrenoceptor)_Rattus norvegicus1656955
7GPCR0236ADRENOCEPTOR (A2-ADRENOCEPTOR)_A2A(Adrenoceptor)_Rattus norvegicus8662784
8GPCR0411ANGIOTENSIN RECEPTOR_AT1_Rattus norvegicus-18865167
9GPCR0430ANGIOTENSIN RECEPTOR_AT1_Rattus norvegicus-28865167
10GPCR0464BRADYKININ RECEPTOR_B1_Rattus norvegicus1657928
11GPCR0473BRADYKININ RECEPTOR_B2_Rattus norvegicus1657928
12GPCR0447BOMBESIN RECEPTOR_BB1_Rattus norvegicus8531502
13GPCR0451BOMBESIN RECEPTOR_BB2_Rattus norvegicus8531502
14GPCR0994LEUKOTRIENE RECEPTOR_BLT_Rattus norvegicus9177352
15GPCR2578CALCITONIN, AMYLIN, CGRP, AND ADRENOMEDULIN RECEPTOR_CALCITONIN_Rattus norvegicus8732687
16GPCR2639EXTRACELLULAR CALCIUM-SENSING RECEPTOR_CASR_Rattus norvegicus8255296
17GPCR0735CHOLECYSTOKININ AND GASTRIN RECEPTOR_CCK1_Rattus norvegicus8503909
18GPCR0744CHOLECYSTOKININ AND GASTRIN RECEPTOR_CCK2_Rattus norvegicus1280419
19GPCR2582CALCITONIN, AMYLIN, CGRP, AND ADRENOMEDULIN RECEPTOR_CGRP_Rattus norvegicus2536720
20GPCR0999LEUKOTRIENE RECEPTOR_CYSLT-1_Rattus norvegicus10391245
21GPCR1003LEUKOTRIENE RECEPTOR_CYSLT-2_Rattus norvegicus10913337
22GPCR2421PROSTANOID RECEPTOR_EP1_Rattus norvegicus8253813
23GPCR2427PROSTANOID RECEPTOR_EP3_Rattus norvegicus11095474
24GPCR0817ENDOTHELIN RECEPTOR_ET-A_Rattus norvegicus1849646
25GPCR0824ENDOTHELIN RECEPTOR_ET-B_Rattus norvegicus1848367
26GPCR2443PROSTANOID RECEPTOR_FP_Rattus norvegicus8300593
27GPCR2730FRIZZLED_Frizzled-1_Rattus norvegicus11563835
28GPCR2737FRIZZLED_Frizzled-2_Rattus norvegicus11563835
29GPCR0836GALANIN RECEPTOR_GAL2_Rattus norvegicus9685625
30GPCR0909GONADOTROPIN-RELEASING HORMONE RECEPTOR_GNRH1_Rattus norvegicus1333190
31GPCR2607GROWTH HORMONE RELEASING PEPTIDES RECEPTOR_Growth hormone secretagogue receptor type 1(Ghrelin receptor)_Rattus norvegicus8688086
32GPCR0966HISTAMINE RECEPTOR_H1_Rattus norvegicus1722337
33GPCR1005LYSOPHOSPHOLIPID RECEPTOR_LPA1_Rattus norvegicus9600933
34GPCR1014LYSOPHOSPHOLIPID RECEPTOR_LPA3_Rattus norvegicus12215548
35GPCR0865GLYCOPROTEIN HORMONE RECEPTOR_LSH RECEPTOR_Rattus norvegicus1516719
36GPCR0121ACETYLCHOLINE RECEPTOR (MUSCARINIC)_M1_Rattus norvegicus3037705
37GPCR0141ACETYLCHOLINE RECEPTOR (MUSCARINIC)_M3_Rattus norvegicus11242080
38GPCR0160ACETYLCHOLINE RECEPTOR (MUSCARINIC)_M5_Rattus norvegicus3037705
39GPCR2797MELANIN-CONCENTRATING HORMONE RECEPTOR_MCHR1_Rattus norvegicus-210559938
40GPCR2648GLUTAMATE RECEPTOR (METABOTROPIC)_MGLU1_Rattus norvegicus9076744
41GPCR2659GLUTAMATE RECEPTOR (METABOTROPIC)_MGLU5_Rattus norvegicus7908515
42GPCR1234NEUROMEDIN RECEPTOR_Neuromedin U 1_Rattus norvegicus10894543
43GPCR1237NEUROMEDIN RECEPTOR_Neuromedin U 2_Rattus norvegicus10894543
44GPCR2498TACHYKININ RECEPTOR_NK1_Rattus norvegicus1370820
45GPCR2511TACHYKININ RECEPTOR_NK2_Rattus norvegicus1370820
46GPCR2514TACHYKININ RECEPTOR_NK3_Rattus norvegicus1370820
47GPCR1273NEUROTENSIN RECEPTOR_NTS1_Rattus norvegicus8381365
48GPCR1276NEUROTENSIN RECEPTOR_NTS2_Rattus norvegicus8647296
49GPCR2364OREXIN RECEPTOR_Orexin 1_Rattus norvegicus9491897
50GPCR2369OREXIN RECEPTOR_Orexin 2_Rattus norvegicus9491897
51GPCR2554VASOPRESSIN AND OXYTOCIN RECEPTOR_OT_Rattus norvegicus1313946
52GPCR2372P2Y RECEPTOR_P2Y1_Rattus norvegicus8159738
53GPCR2390P2Y RECEPTOR_P2Y2_Rattus norvegicus8159738
54GPCR2398P2Y RECEPTOR_P2Y4_Rattus norvegicus9396022
55GPCR2406P2Y RECEPTOR_P2Y6_Rattus norvegicus7592819
56GPCR2620VASOACTIVE INTESTINAL PEPTIDE AND PITUITARY ADENYLATE CYCLASE ACTIVATING PEPTIDE RECEPTOR_PAC1_Rattus norvegicus8396727
57GPCR2455PROTEASE-ACTIVATED RECEPTOR_PAR1_Rattus norvegicus10644723
58GPCR2460PROTEASE-ACTIVATED RECEPTOR_PAR2_Rattus norvegicus15082510
59GPCR2464PROTEASE-ACTIVATED RECEPTOR_PAR3_Rattus norvegicus15082510
60GPCR2465PROTEASE-ACTIVATED RECEPTOR_PAR4_Rattus norvegicus15082510
61GPCR2411PLATELET ACTIVATING FACTOR (PAF) RECEPTOR_PLATELET ACTIVATING FACTOR (PAF) RECEPTOR_Rattus norvegicus7876256
62GPCR2414PROLACTIN RELEASING PEPTIDE RECEPTOR (PRRPR)_PrRP_Rattus norvegicus11030716
63GPCR1088LYSOPHOSPHOLIPID RECEPTOR_S1P2_Rattus norvegicus10617617
64GPCR1094LYSOPHOSPHOLIPID RECEPTOR_S1P3_Rattus norvegicus9409733
65GPCR2450PROSTANOID RECEPTOR_TP_Rattus norvegicus8300593
66GPCR2520THYROTROPIN-RELEASING HORMONE RECEPTOR_TRH1_Rattus norvegicus2175902
67GPCR0881GLYCOPROTEIN HORMONE RECEPTOR_TSH RECEPTOR_Rattus norvegicus8552586
68GPCR2548UROTENSIN RECEPTOR_UROTENSIN II RECEPTOR_Rattus norvegicus10499587
69GPCR2562VASOPRESSIN AND OXYTOCIN RECEPTOR_V1A_Rattus norvegicus1560825
70GPCR2565VASOPRESSIN AND OXYTOCIN RECEPTOR_V1B_Rattus norvegicus11091117
71GPCR1246NEUROPEPTIDE Y RECEPTOR_Y1_Rattus norvegicus1321422



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