gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::Effector View
Entry 1 of 1 :: EFF0439 ::
FAMILY Guanine nucleotide exchange factors
SUBFAMILY RhoGEFs
TYPE LARG RhoGEF

Cross References:
UniProt Q8R4H2 | Q80U18 EMBL AF467766 | AK122267
InterPro IPR000219 | IPR001331 | IPR001478 | IPR001849 | IPR011993 | IPR015212 | IPR015721
PFAM PF00595 | PF09128 | PF00621

Details:
NAME LARG RhoGEF-Mus musculus-4
DESCRIPTION Rho guanine nucleotide exchange factor 12 (Leukemia-associatedRhoGEF).
SPECIES Mus musculus COMMON NAME Mouse NCBI Taxonomy 10090
GENE Arhgef12 | Kiaa0382 | Larg
SEQUENCE 
MSGTQSTITDRFPLKKPIRHGSILNRESPTDKKQKVERSSSHDFDPTDSSSKKTKSSSEE
SRSEIYGLVQRCVIIQKDDNGFGLTVSGDNPVFVQSVKEDGAAMRAGVQTGDRIIKVNGT
LVTHSNHLEVVKLIRSGSYVALTVQGRPPGSPQIPLADSEVEPSVTGHMSPIMTSPHSPG
AAGNMERITSPVLVGEENNVVHNQKVEILRKMLQKEQERLQLLQEDYNRTATQRLLKEIQ
EAKKHIPQLQEQLSK
 FRAGMENT NO
FUNCTION May play a role in the regulation of RhoA GTPase bys guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13)
Interacting with G-proteins:
Family:G12/13 REFERENCES:15251227 | 12024019 | 14607242
1GPR0035Galpha-12-Mus musculus
2GPR0038Galpha-13-Mus musculus-2
3GPR0323Galpha-13-Mus musculus-3
4GPR0380Galpha-13-Mus musculus-1
Family:Gq/11 REFERENCES:15251227 | 12024019
5GPR0240Galpha-q-Mus musculus

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