gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
Introduction Navigation Text Search Blast Search Pattern Search User Manual

gpDB::G-protein View
Entry 1 of 1 :: GPR0035 ::
CLASS Galpha
FAMILY G12/13
SUBFAMILY Galpha-12
TYPE Galpha-12

Cross References:
UniProt P27600 EMBL M63659 | M57618
InterPro IPR001019 | IPR000469 | IPR011025 PDB 1ZCA
PRODOM PD000281
GENEID 14673
PRINTS PR00318 | PR00440 PFAM PF00503

Details:
NAME Galpha-12-Mus musculus
DESCRIPTION Guanine nucleotide-binding protein alpha-12 subunit (G alpha-12).
SPECIES Mus musculus COMMON NAME Mouse NCBI Taxonomy 10090
POST TRANSLATION MODIFICATIONS null GENE Gna12 | Gna-12
SEQUENCE 
MSGVVRTLSRCLLPAEAGARERRAGAARDAEREARRRSRDIDALLARERRAVRRLVKILL
LGAGESGKSTFLKQMRIIHGREFDQKALLEFRDTIFDNILKGSRVLVDARDKLGIPWQHS
ENEKHGMFLMAFENKAGLPVEPATFQLYVPALSALWRDSGIREAFSRRSEFQLGESVKYF
LDNLDRIGQLNYFPSKQDILLARKATKGIVEHDFVIKKIPFKMVDVGGQRSQRQKWFQCF
DGITSILFMVSSSEYDQVLMEDRRTNRLVESMNIFETIVNNKLFFNVSIILFLNKMDLLV
EKVKSVSIKKHFPDFKGDPHRLEDVQRYLVQCFDRKRRNRSKPLFHHFTTAIDTENIRFV
FHAVKDTILQENLKDIMLQ
 FRAGMENT NO
FUNCTION Guanine nucleotide-binding proteins (G proteins) ares involved as modulators or transducers in various transmembranes signaling systems
Effectors:
1EFF0329E cadherin-Mus musculus-1Stimulation (stimulation of h-catenin release)15251227 | 14607242 | 11136230
2EFF0330E cadherin-Mus musculus-2Stimulation (stimulation of h-catenin release)15251227 | 14607242 | 11136230
3EFF0436LARG RhoGEF-Mus musculus-1Stimulation (indirect activation of Rho and stress fiber formation)15251227 | 12024019 | 14607242
4EFF0437LARG RhoGEF-Mus musculus-2Stimulation (indirect activation of Rho and stress fiber formation)15251227 | 12024019 | 14607242
5EFF0438LARG RhoGEF-Mus musculus-3Stimulation (indirect activation of Rho and stress fiber formation)15251227 | 12024019 | 14607242
6EFF0439LARG RhoGEF-Mus musculus-4Stimulation (indirect activation of Rho and stress fiber formation)15251227 | 12024019 | 14607242
7EFF0447PDZ RhoGEF-Mus musculus-1Stimulation (indirect activation of Rho and stress fiber formation)15251227 | 11799111 | 14607242
8EFF0448PDZ RhoGEF-Mus musculus-2Stimulation (indirect activation of Rho and stress fiber formation)15251227 | 11799111 | 14607242
9EFF0449PDZ RhoGEF-Mus musculus-3Stimulation (indirect activation of Rho and stress fiber formation)15251227 | 11799111 | 14607242
10EFF0450PDZ RhoGEF-Mus musculus-4Stimulation (indirect activation of Rho and stress fiber formation)15251227 | 11799111 | 14607242
11EFF0451PDZ RhoGEF-Mus musculus-5Stimulation (indirect activation of Rho and stress fiber formation)15251227 | 11799111 | 14607242
12EFF0694Ras GTPase activating protein-2-Mus musculusStimulation (indirect activation of ras)15251227

Coupling with GPCRs:
1GPCR00855-HYDROXYTRYPTAMINE RECEPTOR_5-HT-2C_Mus musculus14722258 | 11572865
2GPCR00915-HYDROXYTRYPTAMINE RECEPTOR_5-HT-4_Mus musculus11923294
3GPCR0208ADRENOCEPTOR (A1-ADRENOCEPTOR)_A1A(Adrenoceptor)_Mus musculus12433842
4GPCR0409ANGIOTENSIN RECEPTOR_AT1_Mus musculus-29092554 | 9287322
5GPCR0421ANGIOTENSIN RECEPTOR_AT1_Mus musculus-19092554 | 9287322
6GPCR0474BRADYKININ RECEPTOR_B2_Mus musculus7946358
7GPCR0452BOMBESIN RECEPTOR_BB2_Mus musculus11507098
8GPCR0704CHEMOTACTIC PEPTIDE RECEPTOR_C3A_Mus musculus12165538
9GPCR2636EXTRACELLULAR CALCIUM-SENSING RECEPTOR_CASR_Mus musculus12954603
10GPCR0733CHOLECYSTOKININ AND GASTRIN RECEPTOR_CCK1_Mus musculus12853286
11GPCR0815ENDOTHELIN RECEPTOR_ET-A_Mus musculus10364236
12GPCR0823ENDOTHELIN RECEPTOR_ET-B_Mus musculus10199825
13GPCR0837GALANIN RECEPTOR_GAL2_Mus musculus10980593
14GPCR1009LYSOPHOSPHOLIPID RECEPTOR_LPA1_Mus musculus9600933
15GPCR1011LYSOPHOSPHOLIPID RECEPTOR_LPA2_Mus musculus12215548
16GPCR1016LYSOPHOSPHOLIPID RECEPTOR_LPA3_Mus musculus12069829
17GPCR0118ACETYLCHOLINE RECEPTOR (MUSCARINIC)_M1_Mus musculus10821841
18GPCR0136ACETYLCHOLINE RECEPTOR (MUSCARINIC)_M3_Mus musculus11036069
19GPCR2500TACHYKININ RECEPTOR_NK1_Mus musculus8999927
20GPCR2453PROTEASE-ACTIVATED RECEPTOR_PAR1_Mus musculus12954641
21GPCR1087LYSOPHOSPHOLIPID RECEPTOR_S1P2_Mus musculus10488065
22GPCR1096LYSOPHOSPHOLIPID RECEPTOR_S1P3_Mus musculus10488065
23GPCR1102LYSOPHOSPHOLIPID RECEPTOR_S1P5_Mus musculus10799507
24GPCR2802SMOOTHENED_smoothened_Mus musculus14723707
25GPCR2452PROSTANOID RECEPTOR_TP_Mus musculus10318854
26GPCR0897GLYCOPROTEIN HORMONE RECEPTOR_TSH RECEPTOR_Mus musculus-18552586
27GPCR2560VASOPRESSIN AND OXYTOCIN RECEPTOR_V1A_Mus musculus10364236



Designed for viewing with Internet Explorer 4 or above, Netscape 6 or above.
contact biodbbiol.uoa.gr
for comments, corrections and
data (sequence) submission.
athina University of Athens
 Faculty of Biology
 Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory