gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::Effector View
Entry 1 of 1 :: EFF0854 ::
FAMILY Tyr protein kinases
SUBFAMILY Tyr protein kinases
TYPE Src tyrosine kinase

Cross References:
UniProt P41240 | Q2M3N2 | Q6FGZ6 EMBL X60114 | X59932 | X74765 | CR541960 | DQ075211 | BC104847 | BC104875 | BC106073
InterPro IPR015778 | IPR000719 | IPR000980 | IPR001452 | IPR001245 | IPR008266 PDB 1BYG | 1CSK
PRODOM PD000001 | PD000093 | PD000066 GENEID 1445 MIM 124095
PRINTS PR00401 | PR00452 | PR00109 PFAM PF07714 | PF00017 | PF00018

Details:
NAME Src tyrosine kinase-Homo sapiens-3
DESCRIPTION Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein-tyrosine kinase CYL).
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
GENE CSK
SEQUENCE 
MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGII
PANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCV
SCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQ
DEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVM
TQLRHSNLVQLLGVI
 FRAGMENT NO
FUNCTION Specifically phosphorylates 'Tyr-504' on LCK, which actss as a negative regulatory site
Interacting with G-proteins:
Family:Gi/o REFERENCES:11007482 | 15251227 | 12209124
1GPR0109Galpha-i3-Homo sapiens
2GPR0218Galpha-i1-Homo sapiens-1
3GPR0226Galpha-i2-Homo sapiens-2
4GPR0261Galpha-i1-Homo sapiens-2
5GPR0365Galpha-i2-Homo sapiens-1
6GPR0020Galpha-o1-Homo sapiens
7GPR0334Galpha-o-Homo sapiens
Family:Gs REFERENCES:11007482 | 15251227 | 12209124
8GPR0119Galpha-s-Homo sapiens-2
9GPR0263Galpha-s-Homo sapiens-4
10GPR0266Galpha-s-Homo sapiens-5
11GPR0267Galpha-s-Homo sapiens-6
12GPR0277Galpha-s-Homo sapiens-7
13GPR0278Galpha-s-Homo sapiens
14GPR0395Galpha-s-Homo sapiens-3

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athina University of Athens
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