gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0131 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY ACETYLCHOLINE RECEPTOR (MUSCARINIC)
SUBFAMILY M2

Cross References:
UniProt Q8VH27 EMBL AY072059
InterPro IPR000276 | IPR001065 | IPR000995 GPCRDB Q8VH27_CAVPO
PRINTS PR00237 | PR00243 | PR00539 PFAM PF00001

Details:
NAME ACETYLCHOLINE RECEPTOR (MUSCARINIC)_M2_Cavia porcellus
DESCRIPTION Muscarinic receptor 2 .
SPECIES Cavia porcellus COMMON NAME Guinea pig NCBI Taxonomy 10141
GENE GPM2
SEQUENCE
MNNSTNSSNNSLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
FLFSLACADLIIGVFSMNLYTLYTVIGFWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRI
VKPNNNNMPGSDSALEHNKIQNGKTPRGVVTENCVQGEEKESSNDSTSVSAVASNMRDDE
ITQDENTISTSLGQTKDENSKQTCIKIVTKTQKGDSGTPSHTTVELVGSSGQNGDEKQNI
VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCASCVPNT
VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
FRAGMENT YES

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Dimerization:
HETERODIMER INFORMATION Forms heterodimers with Muscarinic M3 Receptors. Heterodimerization results in altered internalization of the receptors METHOD Chimeric receptor reconstitution studies REFERENCES 10490911

Coupling with G-proteins:
Family:Gi/o REFERENCES:3443095
1GPR0107Galpha-i3-Cavia porcellus
2GPR0216Galpha-i1-Cavia porcellus
3GPR0224Galpha-i2-Cavia porcellus


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athina University of Athens
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Biophysics
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