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gpDB::G-protein View
Entry 1 of 1 :: GPR0224 ::
CLASS Galpha
FAMILY Gi/o
SUBFAMILY Galpha-i
TYPE Galpha-i2

Cross References:
UniProt P38402 EMBL D21233
InterPro IPR001019 | IPR001408 | IPR011025
PRODOM PD000281
PRINTS PR00318 | PR00441 PFAM PF00503

Details:
NAME Galpha-i2-Cavia porcellus
DESCRIPTION Guanine nucleotide-binding protein G(i), alpha-2 subunit (Adenylatecyclase-inhibiting G alpha protein).
SPECIES Cavia porcellus COMMON NAME Guinea pig NCBI Taxonomy 10141
POST TRANSLATION MODIFICATIONS null GENE GNAI2
SEQUENCE 
MGCTVSAEDKAAAERSKMIDKNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEDG
YSEEECRQYRAVVYSNTIQSIMAIVKAMGNLQIDFADPLRADDARQLFALSCTAEEQGML
PEDLSGVIRRLWADHGVQACFSRSREYQLNDSAAYYLNDLDRIAQSDYIPTQQDVLRTRV
KTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSAYDLVLAEDEE
MNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKITHSPLTICFPEYTGANKYDEA
ASYIQSKFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF
 FRAGMENT NO
FUNCTION Guanine nucleotide-binding proteins (G proteins) ares involved as modulators or transducers in various transmembranes signaling systems
Effectors:
1EFF0395Kir 3.1(GIRK1)-Cavia porcellusStimulation15251227 | 14963032 | 11779482
2EFF0620Rac-Cavia porcellus-1Stimulation11099498
3EFF0621Rac-Cavia porcellus-2Stimulation11099498

Coupling with GPCRs:
1GPCR00245-HYDROXYTRYPTAMINE RECEPTOR_5-HT-1B_Cavia porcellus1351684
2GPCR00375-HYDROXYTRYPTAMINE RECEPTOR_5-HT-1D_Cavia porcellus-11565658
3GPCR00445-HYDROXYTRYPTAMINE RECEPTOR_5-HT-1D_Cavia porcellus-21565658
4GPCR00555-HYDROXYTRYPTAMINE RECEPTOR_5-HT-1F_Cavia porcellus8384716
5GPCR0170ADENOSINE RECEPTOR_A1_Cavia porcellus1662665
6GPCR0234ADRENOCEPTOR (A2-ADRENOCEPTOR)_A2A(Adrenoceptor)_Cavia porcellus8662784
7GPCR0246ADRENOCEPTOR (A2-ADRENOCEPTOR)_A2B(Adrenoceptor)_Cavia porcellus-22164221
8GPCR0247ADRENOCEPTOR (A2-ADRENOCEPTOR)_A2B(Adrenoceptor)_Cavia porcellus-12164221
9GPCR0298ADRENOCEPTOR (A2-ADRENOCEPTOR)_A2C(Adrenoceptor)_Cavia porcellus2842764
10GPCR0412ANGIOTENSIN RECEPTOR_AT1_Cavia porcellus-11310139
11GPCR0423ANGIOTENSIN RECEPTOR_AT1_Cavia porcellus-21310139
12GPCR0392ADRENOCEPTOR (B-ADRENOCEPTOR)_B3(Adrenoceptor)_Cavia porcellus9363896
13GPCR0703CHEMOTACTIC PEPTIDE RECEPTOR_C3A_Cavia porcellus8702752
14GPCR0708CHEMOTACTIC PEPTIDE RECEPTOR_C5A_Cavia porcellus7887933
15GPCR0568CHEMOKINE RECEPTOR (CC)_CCR3_Cavia porcellus8631813
16GPCR0854GLYCOPROTEIN HORMONE RECEPTOR_FSH RECEPTOR_Cavia porcellus9139796
17GPCR0983HISTAMINE RECEPTOR_H3_Cavia porcellus10347254
18GPCR0986HISTAMINE RECEPTOR_H4_Cavia porcellus10973974
19GPCR1888OPIOID AND OPIOID-LIKE RECEPTOR_KAPPA OPIOID PEPTIDE (KOR)_Cavia porcellus7624359
20GPCR1010LYSOPHOSPHOLIPID RECEPTOR_LPA1_Cavia porcellus9070858
21GPCR0131ACETYLCHOLINE RECEPTOR (MUSCARINIC)_M2_Cavia porcellus3443095
22GPCR0154ACETYLCHOLINE RECEPTOR (MUSCARINIC)_M4_Cavia porcellus3037705
23GPCR1911OPIOID AND OPIOID-LIKE RECEPTOR_MU OPIOID PEPTIDE (MOR)_Cavia porcellus8393525
24GPCR1914OPIOID AND OPIOID-LIKE RECEPTOR_N/OFQ RECEPTOR_Cavia porcellus15019559
25GPCR2410PLATELET ACTIVATING FACTOR (PAF) RECEPTOR_PLATELET ACTIVATING FACTOR (PAF) RECEPTOR_Cavia porcellus7876256
26GPCR1062LYSOPHOSPHOLIPID RECEPTOR_S1P1_Cavia porcellus9488656
27GPCR1089LYSOPHOSPHOLIPID RECEPTOR_S1P2_Cavia porcellus10488065
28GPCR1243NEUROPEPTIDE Y RECEPTOR_Y1_Cavia porcellus1321422
29GPCR1253NEUROPEPTIDE Y RECEPTOR_Y2_Cavia porcellus7559383



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