gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0172 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY ADENOSINE RECEPTOR
SUBFAMILY A1

Cross References:
UniProt P28190 | A5PJR1 | Q58D38 EMBL X63592 | M86261 | BT021759 | BC142208 | BC142265
InterPro IPR001068 | IPR001634 | IPR000276 GPCRDB AA1R_BOVIN
GENEID 282133
PRINTS PR00552 | PR00424 | PR00237 PFAM PF00001

Details:
NAME ADENOSINE RECEPTOR_A1_Bos taurus
DESCRIPTION Adenosine receptor A1.
SPECIES Bos taurus COMMON NAME Bovine NCBI Taxonomy 9913
GENE ADORA1
SEQUENCE
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA
LVIPLAILINIGPRTYFHTCLKVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVT
PRRAVVAITGCWILSFVVGLTPMFGWNNLSAVERDWLANGSVGEPVIECQFEKVISMEYM
VYFNFFVWVLPPLLLMVLIYMEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL
FLFALSWLPLHILNCITLFCPSCHMPRILIYIAIFLSHGNSAMNPIVYAFRIQKFRVTFL
KIWNDHFRCQPAPPVDEDAPAERPDD
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12123822
HETERODIMER INFORMATION Forms heterodimers with Dopamine D1 Receptor. Heterodimerization results in altered D1 receptor signalling METHOD Immunoprecipitation REFERENCES 10890919
HETERODIMER INFORMATION Forms heterodimers with Metabotropic Glutamate Receptor 1. Dimerization results in alteration of signalling METHOD Immunoprecipitation REFERENCES 11278325
HETERODIMER INFORMATION Forms heterodimers with P2Y1 Receptors. Heterodimerization results in altered ligand binding METHOD Immunoprecipitation, Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 11390975 | 12417330 | 12123822

Coupling with G-proteins:
Family:Gi/o REFERENCES:1662665
1GPR0017Galpha-o1-Bos taurus
2GPR0219Galpha-i1-Bos taurus
3GPR0294Galpha-i2-Bos taurus-2
4GPR0295Galpha-i2-Bos taurus-1


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory