gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0181 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY ADENOSINE RECEPTOR
SUBFAMILY A2A

Cross References:
UniProt Q9R1I7 EMBL AF107208
InterPro IPR001513 | IPR001634 | IPR000276 GPCRDB Q9R1I7_RAT
PRINTS PR00553 | PR00424 | PR00237 PFAM PF00001

Details:
NAME ADENOSINE RECEPTOR_A2A_Rattus norvegicus-2
DESCRIPTION A2a adenosine receptor .
SPECIES Rattus norvegicus COMMON NAME Rat NCBI Taxonomy 10116
GENE Adora2a
SEQUENCE 
MGSSVYITVELAIAVLAILGNVLVCWAVWINSNLQNVTNFFVVSLAAADIAVGVLAIPFA
ITISTGFCAACHGCLFFACFVLVLTQSSIFSLLAIAIDRYIAIRI
 FRAGMENT YES

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12804599
HETERODIMER INFORMATION Forms heterodimers with Dopamine D2. Heterodimerization results in co-desensitization and co-internalization of the receptors METHOD Immunoprecipitation REFERENCES 11872740
HETERODIMER INFORMATION Forms heterodimers with Metabotropic Glutamate Receptors 5. Dimerization results in enhanced ERK activity METHOD Immunoprecipitation REFERENCES 12189203

Coupling with G-proteins:
Family:Gs REFERENCES:1662665
1GPR0124Galpha-s-Rattus norvegicus-2
2GPR0392Galpha-s-Rattus norvegicus-1

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athina University of Athens
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